摘要
目的探讨洛阳市创业路社区2型糖尿病患病中肾病(KD)的患病情况及其相关因素。方法 2018年1~8月,采用方便抽样对273例2型糖尿病(T2DM)患者为调查对象。根据尿微量白蛋白/肌酐比值(UACR),将T2DM患者分为大量白蛋白尿(UACR>300mg/g)、微量白蛋白尿组(UACR 30~300mg/g)、正常白蛋白尿组(UACR<30mg/g)组,以大量白蛋白尿组、微量白蛋白尿组作为糖尿病肾病病例组(DKD组),以正常白蛋白尿组作为对照组(糖尿病,DM组)。比较两者年龄、性别构成、糖尿病病程、血压(收缩压、舒张压)、血脂[总胆固醇(TC)、甘油三酯(TG)]、糖化血红蛋白(HbA1c)、尿微量白蛋白、尿素、血肌酐、尿肌酐、心血管疾病及高血压患病率,并探讨DKD发生的危险因素。结果洛阳市创业路社区T2DM患者DKD 58例,患病率为21.24%,其中54例(19.78%)为微量蛋白尿期,4例(1.46%)为临床白蛋白尿期。DM组与DKD组患者在血压(P <0.01)、血脂(P <0.01)、HbA1c(P <0.01)、糖尿病病程(P <0.01)、尿微量白蛋白(P <0.01)、尿白蛋白肌酐比值(UCAR)(P <0.01)、尿素(P <0.05)、血肌酐(P <0.05)、eGFR<60(ml/min/1.73m2)比率(P <0.01)及高血压患病率(P <0.01)比较,差异均有统计学意义。两组之间性别、年龄、心血管疾病史、BMI、腰臀比差异无统计学意义(P>0.05)。纳入的273例患者中124例BMI<24kg/m^(2),达标率为46.52%。TC达标率为55.31%;TG达标率为58.60%。女性HDL达标率低于男性(P>0.05)。单因素分析结果显示,DKD发生的风险可能与患者的年龄(P <0.05)、糖尿病病程>10年(P <0.01)、是否合并高血压(P <0.01)、糖化血红蛋白(P <0.01)、血脂(P <0.01)、血肌酐(P <0.01)、血尿素氮(P <0.01)、eGFR(P <0.05)等因素相关(P <0.05)。多因素Logistic分析结果显示:糖尿病病程(P <0.01)、是否合并高血压(P <0.05)、糖化血红蛋白(P <0.01)、血脂异常(P <0.01)均是2型糖尿病合并KD的独立危险因素(P <0.05)。结论洛阳市创业路社区DKD患�
Objective To explore the status and related factors of nephropathy among type 2 diabetic patients in Chuangye road community of Luoyang city. Methods A total of 273 patients with type 2 diabetes mellitus(T2 DM)were investigated by convenience sampling from January to August 2018.According to the urine trace albumin/creatinine ratio(UACR),DKD patients can be divided into a lot of albuminuria(UACR >300 mg/g),microalbuminuria group(UACR30-300 mg/g)and normal albuminuria group(UACR <30 mg/g)group,with a large number of albuminuria group,microalbuminuria group as a case group(DKD group),with normal albuminuria group as a control group(DM group).Comparison between age,gender,duration of diabetes,blood pressure(systolic pressure,diastolic blood pressure),blood lipid[total cholesterol(TC),triglyceride(TG)],glycosylated hemoglobin(HbA1 c),urine trace albumin,urea,creatinine,uric creatinine,cardiovascular disease and hypertension prevalence,risk factors and DKD was discussed.Results The prevalence of DKD among T2 DM patients in Chuangye road community of Luoyang city was 21.24%(58 patients),of which 54 patients(19.78%)were in the microalbuminuria stage and 4 patients(1.46%)were in the clinical albuminuria stage.There were statistically significant differences in blood pressure(P <0.01),blood lipid(P <0.01),HbA1 c(P <0.01),duration of diabetes(P <0.01),urinary microalbumin (P <0.01),urinary albumin creatinine ratio(UACR)(P <0.01),urea(P <0.05),serum creatinine(P <0.05),eGFR<60(ml/min/1.73 m2)(P <0.01)and the prevalence of hypertension(P <0.01)between DM group and DKD group(P<0.05).There were no significant differences between the two groups in gender,age,history of cardiovascular disease,BMI and waist-hip ratio.Among the 273 included patients,124 patients(46.52%)had a BMI<24 kg/m^(2),TC compliance rate of 55.31%;The TG compliance rate was 58.60%.The meeting rate of high density lipoprotein(HDL)in female patients was significantly lower than that in male patients,with no statistically significant difference(P >0.05).Univaria
作者
刘鹏
武洪利
李利平
黄娟
白金磊
符玮
胡可嫣
李佳熙
张知音
LIU Peng;WU Hong-li;LI Li-ping;HUANG Juan;BAI Jin-lei;FU Wei;HU Ke-yan;LI Jia-xi;ZHANG Zhi-yin(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan,471000,China;不详)
出处
《预防医学论坛》
2021年第8期575-578,582,共5页
Preventive Medicine Tribune
基金
2018年河南省医学科技攻关计划联合共建项目——探讨可穿戴运动设备在社区糖尿病慢病管理中的应用(项目编号:2018020281)
2017年河南省省直医疗机构服务能力提升工程建设项目(2017-51)。
关键词
糖尿病
2型
糖尿病肾病
危险因素
Diabetes
Type 2
Diabetic nephropathy
Risk factors
Prevalence
