摘要
目的探讨围绝经期及绝经后女性骨密度与性激素以及人体成分的相关性。方法选择2019年11月至2021年6月中山市博爱医院就诊的围绝经期及绝经后女性162例为研究对象,采用双能X线吸收检测仪(DXA)检测腰椎_(2-4)及左侧股骨颈骨密度(BMD)和骨矿含量(BMC),采用人体成分分析仪测定人体成分,根据测定结果分为正常组(n=83)、骨量减少组(n=59)和骨质疏松组(n=20)。比较不同年龄段骨质疏松和肌少症的患病率,探讨BMD与性激素、人体成分之间的关系,进一步分析骨质疏松的影响因素。结果162例研究对象中骨质疏松20例(12.35%),肌少症15例(9.26%),不同年龄组骨质疏松患病率比较差异有统计学意义(χ^(2)=7.099,P<0.05),>60岁年龄组患病率显著高于40~50岁和51~60岁年龄组(χ^(2)值分别为4.993、5.198,均P<0.05),不同年龄组肌少症患病率比较差异无统计学意义(χ^(2)=2.794,P>0.029)。三组不同骨密度患者血清FSH、LH、E_(2)、DHEAS水平比较差异均有统计学意义(F值为3.216~4.357,P<0.05),骨质疏松组患者血清FSH、LH水平均显著高于骨量减少组和正常组(t值为3.794~5.218,P<0.05),而骨量减少组患者血清上述指标均显著高于正常组(t值分别为2.425、2.963,P<0.05)。骨质疏松组患者血清E_(2)、DHEAS水平均显著低于骨量减少组和正常组(t值为2.890~5.002,P<0.05),而骨量减少组患者上述指标均显著低于正常组(t值为2.786、2.976,P<0.05)。三组患者人体成分BFM、BFP和BMC比较差异均有统计学意义(F值为2.657、2.598、3.509,P<0.05),骨质疏松组患者上述指标均显著低于骨量减少组和正常组(t值为3.012~4.063,P<0.05),而骨量减少组患者均显著低于正常组(t值为2.379~2.954,P<0.05)。Pearson相关性分析结果表明围绝经期和绝经后女性BMD与FSH、LH、BFM、BFP、BMC均呈显著负相关性(r值为-0.603~-0.811,P<0.05),而均与DHEAS、SMM、E_(2)呈显著正相关(r值为0.563~0.601,P<0.05)。多因素Lo
Objective To investigate the correlation between bone mineral density and sex hormones and body composition of perimenopausal and menopausal women.Methods 162 perimenopausal and menopausal women in Bo′ai hospital of Zhongshan from November 2019 to June 2021 were selected as subjects.Dual-energy X-ray absorptiometry(DXA)was used to detect the bone mineral density of the lumbar spine 2-4 and the left femoral neck(BMD).The body composition was detected by body composition analyzer.According to the measurement results,subjects were divided into normal group(n=83),osteopenia group(n=59)and osteoporosis group(n=20).The prevalence of osteoporosis and sarcopenia in different age groups was compared,the relationship between BMD,sex hormone and body composition was discussed,and the influencing factors of osteoporosis were analyzed.Results There were 20 cases(12.35%)of osteoporosis and 15 cases(9.26%)of sarcopenia among 162 subjects.There were significant differences in the prevalence of osteoporosis among different age groups(χ^(2)=7.099,P<0.05).The prevalence of sarcopenia in>60 years old group was significantly higher than that in 40~50 years old and 51~60 years old group(χ^(2)=4.993 and 5.198,respectively,P<0.05),but there was no significant difference in the prevalence of sarcopenia in different ages(χ^(2)=2.794,P>0.029).There were statistically significant differences in serum FSH,LH,E_(2) and DHEAS levels among three groups(F=3.216~4.357,respectively,P<0.05).Further comparison between the two groups showed that serum FSH and LH levels in osteoporosis group were significantly higher than those in osteopenia group and normal group(t=3.794~5.218,respectively,P<0.05).The above indicators in osteopenia group were significantly higher than those in normal group(t values were 2.425 and 2.963,respectively,all P<0.05).Serum E_(2) and DHEAS levels in osteoporosis group were significantly lower than those in osteopenia group and normal group(t=2.890~5.002,respectively,P<0.05),while above indicators in osteopenia group wer
作者
张静
匡晓梅
严雪文
肖琳
罗小婉
邓伟民
ZHANG Jing;KUANG Xiaomei;YAN Xuewen;XIAO Lin;LUO Xiaowan;DENG Weimin(Department of womens health care,Bo'ai Hospital of Zhongshan,Guangdong Zhongshan,China;Department of gynecology,Bo'ai Hospital of Zhongshan,Guangdong Zhongshan,528400,China;Guangzhou General Hospital of Guangzhou Military Region,Guangdong Guangzhou,510010,China)
出处
《中国妇幼健康研究》
2021年第12期1734-1739,共6页
Chinese Journal of Woman and Child Health Research
基金
总后勤部卫生部保健专项项目(No.16BJZ57)
中山市科技计划项目(编号:2018B1003)。
关键词
骨密度
围绝经期和绝经后
性激素
人体成分
肌少症
bone mineral density
perimenopause and postmenopausal
sex hormones
body composition
correlation
sarcopenia
