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血清和肽素、半乳糖凝集素-3与妊娠期高血压疾病左心室功能下降的相关性

The relationship between the levels of serum copeptin and galectin-3 of the pregnant women with hypertensive disorder complicating pregnancy and their decline of the left ventricular function
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摘要 目的:探讨血清和肽素、半乳糖凝集素-3水平与妊娠期高血压疾病(HDCP)患者左心室功能下降的相关性。方法:2020年1月-2021年5月在本院收治的HDCP患者150例作为观察组,其中妊娠期高血压组89例,子痫前期组61例;同期正常妊娠妇女100例作为对照组。检测各组血清和肽素、半乳糖凝集素-3水平,超声测量并计算左心功能各项指标。比较各组基本资料、血清和肽素、半乳糖凝集素-3水平,左心功能各项指标,并进行Pearson相关性分析和Logistic多因素回归分析。结果:子痫前期组收缩压、舒张压高于妊娠期高血压组及对照组(P<0.05);与对照组及妊娠期高血压组相比,子痫前期患者血清和肽素、半乳糖凝集素-3、B型钠尿肽(BNP)、乳酸脱氢酶(LDH)水平均明显升高(P<0.05),左心室舒张功能指标舒张早期最大流速/舒张晚期最大速度(E/A)值、舒张早期快速充盈分数(RFF)明显降低(P<0.05);随着HDCP病情的加重,子痫前期组患者血清和肽素、半乳糖凝集素-3、BNP、LDH水平较妊娠期高血压增高;HDCP患者血清和肽素、半乳糖凝集素-3水平与心输出量(CO)、左室射血分数(LVEF)、心脏指数(CI)无相关性(P>0.05),与E/A值、RFF均呈负相关(P<0.05);Logistic多因素回归分析显示和肽素、半乳糖凝集素-3、BNP、LDH、收缩压、舒张压是HDCP患者左心室舒张功能损伤的独立危险因素。结论:血清和肽素、半乳糖凝集素-3水平与HDCP患者疾病严重程度相关,是HDCP患者左心室功能下降的危险因素,可能参与左心室功能损伤。 Objective:To investigate the relationship between the levels of serum copeptin and galectin-3 of the pregnant women with hypertensive disorder complicating pregnancy(HDCP)and their decline of the left ventricular function.Methods:150 pregnant women with HDCP were selected in observation group and were divided in group A(89 cases with HDCP)and group B(61 cases with preeclampsia)from June 2020 to May 2021.100 normal pregnant women were selected in control group during the same period.The levels of serum peptide and galectin-3 of the women in the three groups were measured,and the indexes of left ventricular function were measured by ultrasound and were calculated.The basic data,the levels of serum peptide and galectin-3,the left ventricular function index of the women were compared among the three groups.Pearson correlation analysis and Logistic regression analysis were also performed.Results:The values of the systolic and diastolic blood pressure of the women in group B were significantly higher of the women in group A and in the control group(P<0.05).The expression levels of serum copeptin and galectin-3,B-type natriuretic peptide(BNP),and lactate dehydrogenase(LDH)of the women in group B were significantly higher than those of the women in group A and in the control group(P<0.05).The values of maximum early diastolic flow rate/maximum late diastolic velocity(E/A),and the early diastolic rapid filling fraction(RFF)of the women in group B were significantly lower than those of the women in group A and in the control group(P<0.05).With the aggravation of HDCP,the expression levels of serum copeptin galectin-3,BNP,LDH of the women in group B were significantly higher than those of the women in group A.The serum copeptin and galectin-3 levels of the women with HDCP were no correlated with their cardiac output(CO),left ventricular ejection fraction(LVEF),and cardiac index(CI)values(P>0.05),but were negatively correlated with their E/A and RFF values(P<0.05).Logistic multifactor regression analysis showed that the seru
作者 钱警语 陈先侠 郑晨旻 王海霞 QIAN Jingyu;CHEN Xianxia;ZHENG Chenmin;WANG Haixia(Anhui Provincial Maternal and Child Health Care Hospital, Hefei, Anhui Province, 230001;School of Public Health of Anhui Medical University)
出处 《中国计划生育学杂志》 2021年第12期2561-2566,共6页 Chinese Journal of Family Planning
基金 安徽省2018年重点研究和开发计划项目(1804h08020295)。
关键词 妊娠期高血压疾病 左心室心功能 血清和肽素 半乳糖凝集素-3 Hypertensive disorder complicating pregnancy Left ventricular function Serum copeptin Galectin-3
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