摘要
损伤时间推断是法医学实践中的主要工作之一,但准确推断损伤时间一直是国内外尚未解决的难题和研究热点。研究证明,微RNA(microRNA,miRNA)参与皮肤损伤修复的整个过程,由于miRNA的特性优势,有望成为推断皮肤损伤时间的生物学指标。本文综述了miRNA的基本生物学功能、特性、皮肤损伤时间推断研究进展及其存在的主要问题,展望了miRNA在损伤时间推断中的应用和研究前景。
Wound age estimation is one of the major tasks in forensic practice.However,relatively accurate estimation of the wound age is still a conundrum and research spotlight world-widely.Studies show that microRNAs(miRNAs)are involved in the whole process of the skin wound repair,and miRNAs,as biomarkers,might be used to estimate the time of skin injury owing to their characteristic advantage.This paper summarizes the miRNA fundamental function,properties,current research progress in the estimation of wound age,and its limitations,and put forward prospect of potential application and research based on miRNAs in estimation of wound age.
作者
程剑
索胧胧
王林林
赵锐
官大威
CHENG Jian;SUO Long-long;WANG Lin-lin;ZHAO Rui;GUAN Da-wei(Department of Forensic Pathology,School of Forensic Medicine,China Medical University,Shenyang 110122,China;Detachment of Criminal Investigation,Changsha Public Security Bureau,Changsha 430100,China;Judicial Appraisal Center,Affiliated Hospital of Weifang Medical University,Weifang 261000,Shan-dong Province,China)
出处
《法医学杂志》
CAS
CSCD
2021年第6期841-846,858,共7页
Journal of Forensic Medicine
基金
国家自然科学基金资助项目(81871529)。
