摘要
胶质瘤是一种源自神经外胚层胶质细胞的最突出的侵袭性脑恶性肿瘤,是最常见的原发性颅内肿瘤之一。外泌体是细胞通过胞吐分泌的直径为30~150 nm的盘状小泡,几乎所有类型的细胞都分泌外泌体,其广泛存在于血液、尿液、唾液、脑脊液和其他细胞外液中。外泌体包括蛋白质、脂质、microRNA(miRNA)、信使RNA和DNA,其中仅miRNA具有低免疫原性、低毒性、血流稳定性,由于其出色的介导细胞间通讯的能力,尤其是在脑肿瘤进展中,成为了一种有前途的治疗和诊断工具。目前,越来越多的miRNA被发现参与到胶质瘤的发生进展、诊断、治疗和预后的过程中。本文围绕外泌体miRNA在脑胶质瘤的诊断、治疗和预后中的作用综述如下。
Glioma is one of the most common primary intracranial tumors,which is the most prominent invasive brain tumor derived from neuroectodermal glia.Exosomes are discoid vesicles with a diameter of 30-150 nm secreted by cells through exocytosis.Almost all types of cells secrete exosomes,which are widely present in blood,urine,saliva,cerebrospinal fluid and other extracellular fluids.Exosomes include proteins,lipids,microRNA(miRNA),messenger RNA and DNA.Only miRNA has low immunogenicity,low toxicity and blood flow stability.Therefore,it has become a promising therapeutic and diagnostic tool because of its excellent ability to mediate intercellular communication,especially in the progression of brain tumors.At present,more and more miRNAs are found to be involved in the pathogenesis,progression,diagnosis,prognosis and treatment of the glioma.This review will introduce the role of exosome miRNA in the diagnosis,treatment and prognosis of glioma.
作者
赵小玉
李彦东
吴昊
范海
吕明月
沈宇晟
盛成俊
曾加
吴徐超
朱国华
更·党木仁加甫
Zhao Xiaoyu;Li Yandong;Wu Hao;Fan Hai;Lyu Mingyue;Shen Yusheng;Sheng Chengjun;Zeng Jia;Wu Xuchao;Zhu Guohua;Geng Dangmurenjiafu(Department of Neurosurgery Center,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《中华脑科疾病与康复杂志（电子版）》
2021年第6期370-374,共5页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金
新疆维吾尔自治区自然科学基金(2018D01A53)。
