摘要
目的:观察艾司唑仑联合草酸艾司西酞普兰治疗卒中后抑郁伴睡眠障碍的临床效果。方法:选取2019年5月至2021年5月常熟市第二人民医院收治的卒中后抑郁伴睡眠障碍患者60例作为研究对象,随机分为观察组和对照组,每组30例。对照组予艾司唑仑治疗,观察组采用艾司唑仑联合草酸艾司西酞普兰治疗,观察治疗6周后2组患者的HAMD、PSQI、MMSE、Barthel指数、ADL评分情况以及不良反应。结果:观察组的总有效率为93.33%,对照组的总有效率为73.33%,观察组的总有效率高于对照组(P<0.05)。2组患者的HAMD、PSQI评分均较治疗前下降(P<0.05),且观察组的HAMD、PSQI评分均低于对照组(P<0.05)。2组患者治疗后的MMSE、ADL评分均较治疗前升高(P<0.05),且观察组的MMSE、ADL评分高于对照组(P<0.05)。治疗期间观察组的药物不良反应发生率为20.00%,对照组的不良反应发生率为10.00%,2组患者药物不良反应总发生率比较差异无统计学意义(P>0.05)。结论:在卒中后抑郁伴睡眠障碍患者中应用艾司唑仑联合草酸艾司西酞普兰治疗效果较好,能有效缓解患者的焦虑及抑郁情绪、改善其睡眠质量、提高其认知能力及日常生活能力,未增加更多不良反应。
Objective:To observe the clinical effects of estazolam combined with escitalopram oxalate in the treatment of post-stroke depression(PSD)with sleep disorders.Methods:A total of 60 patients with PSD complicated with sleep disorders who were treated in Changshu No.2 People′s Hospital between May 2019 and May 2021 were randomly divided into observation group(n=30)and control group(n=30).The control group was given estazolam,and the observation group was combined with escitalopram oxalate on this basis.The degree of depression[Hamilton Depression Scale(HAMD)],sleep disorders[Pittsburgh Sleep Quality Index(PSQI)],cognitive ability[Mini-Mental State Exercise(MMSE)]and ability of daily living[Barthel Index Activities of Daily Living Scale(ADL)]before treatment and after 6 weeks of treatment and adverse drug reactions during treatment were compared between the two groups.Results:The total effective rate of patients in observation group was higher than that in control group after 6 weeks of treatment(93.33%vs 73.33%),P<0.05.The scores of HAMD and PSQI of the two groups of patients after 6 weeks of treatment were reduced compared with those before treatment,and the scores in observation group were lower compared to control group(P<0.05).The MMSE and ADL scores of the two groups after treatment were higher than those before treatment(P<0.05),and the MMSE and ADL scores of the observation group were higher than those of the control group(P<0.05).During treatment,the incidence of adverse drug reactions in the observation group was 20.00%,and that in the control group was 10.00%.There was no statistical significance in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:Estazolam combined with escitalopram oxalate has better treatment effects on patients with PSD complicated with sleep disorders,and it can effectively relieve the anxiety and depression,improve the sleep quality,and enhance the cognitive ability and ability of daily living,without increasing more adverse reactions.
作者
高善玉
GAO Shanyu(Department of Neurology,Changshu No.2 Hospital,Yangzhou University,Changshu 215500,China)
出处
《世界睡眠医学杂志》
2021年第11期1878-1880,共3页
World Journal of Sleep Medicine
