摘要
目的对比对老年不稳定型心绞痛患者应用不同剂量替格瑞洛联合曲美他嗪治疗的临床效果以及对心功能的影响。方法80例老年不稳定型心绞痛患者,采用随机数字表法分为对照组及观察组,每组40例。对照组给予常规剂量替格瑞洛联合曲美他嗪治疗,观察组给予低剂量替格瑞洛联合曲美他嗪治疗。对比两组患者的临床疗效、治疗前后血清炎性因子指标水平、二磷酸腺苷(ADP)抑制率以及花生四烯酸(AA)抑制率以及不良反应发生情况。结果观察组总有效率为85.00%,与对照组的90.00%对比,差异无统计学意义(P>0.05)。治疗前后,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平组间对比,差异均无统计学意义(P>0.05)。两组ADP及AA抑制率对比,差异无统计学意义(P>0.05)。对照组不良反应发生率为15.00%,与观察组的5.00%对比,差异无统计学意义(P>0.05)。结论老年不稳定型心绞痛患者实施低剂量替格瑞洛联合曲美他嗪治疗,可在减少患者经济压力的同时,取得与常规剂量替格瑞洛联合曲美他嗪治疗基本一致的治疗效果,有较高的临床应用价值。
Objective To compare the clinical effect of different doses of ticagrelor combined with trimetazidine in the treatment of elderly patients with unstable angina pectoris,and its influence on the cardiac functions.Methods A total of 80 elderly patients with unstable angina were divided into control group and observation group by random numerical table,with 40 cases in each group.The control group was treated with conventional doses of ticagrelor combined with trimetazidine,and the observation group was treated with low doses of ticagrelor combined with trimetazidine.The clinical efficacy,serum inflammatory factor indexes before and after treatment,inhibition rate of adenosine diphosphate(ADP)and arachidonic acid(AA)and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 85.00%,which was not statistically significant compared with 90.00%of the control group(P>0.05).Before and after treatment,there was no statistically significant difference in the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)between the two groups(P>0.05).There was no statistically significant difference in inhibirate of ADP and AA between the two groups(P>0.05).The incidence of adverse reactions in the control group was 15.00%,which was not statistically significant compared with 5.00%in the observation group(P>0.05).Conclusion Low-dose ticagrelor combined with trimetazidine treatment for elderly patients with unstable angina pectoris can reduce the economic pressure of patients and achieve the same therapeutic effect as conventional doses of ticagrelor combined with trimetazidine.It has high clinical application value.
作者
谷悦
GU Yue(Department of Geriatrics,Lianshan people’s Hospital,Huludao 125000,China)
出处
《中国现代药物应用》
2022年第3期134-136,共3页
Chinese Journal of Modern Drug Application
关键词
老年不稳定型心绞痛
替格瑞洛
曲美他嗪
血清炎性因子
Unstable angina pectoris in the elderly
Ticagrelor
Trimetazidine
Serum inflammatory factors
