摘要
异时性多原发结直肠癌(MCC)是结直肠癌中的一种特殊分类,在MCC发病过程中,不良生活习惯(高脂饮食、肥胖、吸烟、饮酒等)和结直肠癌手术等是其重要影响因素,改善不良生活习惯可能有助于MCC的治疗。导致MCC发生发展的分子机制复杂,其中林奇综合征相关结直肠癌发生通路在MCC的发生与发展中起重要作用。MCC的治疗以外科治疗为主,但具体术式尚存在争议。MCC的诊断与治疗是未来研究的重点,在基因、转录和翻译水平上探索MCC的治疗靶点将有助于临床诊疗的精准化、个体化。
Metachronous multiple primary colorectal carcinoma(MCC)is a special category of colorectal carcinoma,and unhealthy living habits(high fat diet,obesity,smoking,alcohol consumption,etc.)and colorectal cancer surgery are important influencing factors in the development of MCC.Improving living habits may contribute to the treatment of MCC.The molecular mechanism of MCC is complicated,and Lynch syndrome associated colorectal carcinogenesis pathway plays an important role in the development of MCC.Surgery is the main treatment method of MCC,but the specific operation procedure is still controversial.The diagnosis and treatment of MCC are the focus of future research,and exploring the therapeutic targets of MCC at the gene,transcription and translation levels will be helpful for the precision and individualization of the clinical diagnosis and treatment.
作者
李佳
魏孝礼
白玉贤
LI Jia;WEI Xiaoli;BAI Yuxian(Department of Gastroenterology Ward One,Tumor Hospital Affiliated to Harbin Medical University,Harbin 150081,China)
出处
《医学综述》
CAS
2022年第2期290-295,共6页
Medical Recapitulate
关键词
异时性多原发结直肠癌
危险因素
不良生活习惯
分子机制
外科治疗
Metachronous multiple primary colorectal cancer
Risk factors
Unhealthy living habits
Molecular mechanism
Surgical treatment
