摘要
金属纳米团簇(M NCs)是近年来出现的一类由几个至数百个原子组成的具有超小尺寸结构(<3 nm)的新型功能材料,因其有独特的物理化学性质以及良好的生物相容性,被广泛应用于生物分析、药物输送、医学成像以及肿瘤治疗等领域。最近,利用M NCs作为新型纳米抗菌材料解决细菌感染方面的研究成为热点,已经在抗生素耐药、致病菌的检测和治疗等方面得到了应用,为解决抗感染问题提供了新思路。本文首先介绍了不同M NCs的合成及性质的研究进展,然后根据近几年来国内外的相关研究,综述了单一M NCs及其复合物抗菌效应的应用现状及其作用机制,并对其作为一种新型纳米抗菌材料在实际应用过程中的稳定性、多功能性以及协同抗菌作用存在的问题进行了展望。
Metal nanoclusters(M NCs) are a new type of functional materials, composed of several to hundreds of atoms with an ultra-small size(<3 nm).Due to their unique physical and chemical properties as well as good biocompatibility, M NCs have been widely used in biomedical fields such as bioanalysis, drug delivery, imaging and tumor therapy.Recently, the use of M NCs as new antimicrobial nanomaterials to solve bacterial infection has been gradually developed, and it has been more and more applied in antibiotic resistance, detection and treatment of pathogenic bacterial, which provides a new idea for solving the problem of anti-infection.This review introduces the research progress in the synthesis and properties of different M NCs, focuses on the application of the antibacterial effect of single M NCs and the corresponding complexes as well as the mechanism according to the relevant research at home and abroad in recent years, and looks forward to its stability, versatility and synergistic antimicrobial effect as a new class of nano-antibacterial materials in application.
作者
王玉先
张红漫
朱丽英
江凌
黄和
WANG Yuxian;ZHANG Hongman;ZHU Liying;JIANG Ling;HUANG He(College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211800,China;School of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 211800,China;College of Food Science and Light Industry,Nanjing Tech University,Nanjing 211800,China;College of Pharmaceutical Sciences,Nanjing Tech University,Nanjing 211800,China)
出处
《生物加工过程》
CAS
2022年第1期81-87,共7页
Chinese Journal of Bioprocess Engineering
基金
国家自然科学基金优秀青年基金(31922070)
国家自然科学基金山东联合基金重点项目(U2106228)
江苏省研究生科研与实践创新计划(KYCX20_1033)
南京工业大学优秀博士学位论文培育计划。
关键词
金属纳米团簇
纳米抗菌材料
抗生素耐药
抗菌效应
细菌感染
抗感染
metal nanoclusters(M NCs)
nano-antimicrobial materials
antibiotic resistance
antimicrobial effect
bacterial infections
anti-infection
