摘要
目的:比较瑞舒伐他汀与辛伐他汀对2型糖尿病合并高脂血症患者的临床效果。方法:选取云浮市中医院2019年2月-2021年2月73例2型糖尿病合并高脂血症患者。按随机数字表法将其分为对照组(n=36)和观察组(n=37)。对照组给予二甲双胍联合辛伐他汀治疗,观察组给予二甲双胍联合瑞舒伐他汀治疗。两组患者均连续治疗3个月。比较两组患者治疗前后血糖、血脂指标、炎症因子、临床疗效和胃肠道反应。结果:与治疗前相比,治疗后两组空腹血糖、餐后2 h血糖、糖化血红蛋白、低密度脂蛋白、甘油三酯及总胆固醇水平均下降,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、低密度脂蛋白、甘油三酯及总胆固醇水平均低于对照组(P<0.05);与治疗前相比,治疗后两组高密度脂蛋白升高,观察组高密度脂蛋白高于对照组(P<0.05);观察组总有效率高于对照组(P<0.05);两组胃肠道反应发生率比较差异无统计学意义(P>0.05);治疗后两组超敏C反应蛋白、白介素-6、白介素-18水平较治疗前均下降,观察组超敏C反应蛋白、白介素-6、白介素-18水平均低于对照组(P<0.05)。结论:二甲双胍联合瑞舒伐他汀治疗2型糖尿病合并高脂血症患者较辛伐他汀效果更为理想,可以控制患者的血糖、血脂水平,降低炎症反应,疗效安全可靠。
Objective:To compare the clinical effect of Rosuvastatin and Simvastatin on patients with type 2 diabetes mellitus complicated with hyperlipidemia.Method:A total of 73 patients with type 2 diabetes complicated with hyperlipidemia from February 2019 to February 2021 in Yunfu Hospital of Traditional Chinese Medicine were selected and divided into control group (n=36) and observation group (n=37) according to the random number table method.The control group was given Metformin combined with Simvastatin treatment,and the observation group was given Metformin combined with Rosuvastatin treatment.The two groups were treated for 3 months.The levels of blood glucose,blood lipid and inflammatory factors before and after treatment,the clinical efficacy and gastrointestinal reactions were compared between the two groups.Result:Compared with before treatment,after treatment,fasting glucose,2 h postprandial blood glucose,glycosylated hemoglobin,low density lipoprotein,triacylglycerol and total cholesterol levels in the two groups decreased,the fasting glucose,2 h postprandial blood glucose,glycosylated hemoglobin,low density lipoprotein,triacylglycerol and total cholesterol levels in the observation group were lower than those in control group (P<0.05);compared with before treatment,after treatment,the high-density lipoprotein level in the two groups was increased,the high-density lipoprotein level of the observation group was higher than that of control group (P<0.05);the total effective rate of observation group was higher than that of control group (P<0.05);there was no significant difference in the incidence of gastrointestinal reactions between the two groups (P>0.05);after treatment,the levels of hypersensitive C-reactive protein,interleukin-6 and interleukin-18 in the two groups decreased,and the levels of hypersensitive C-reactive protein,interleukin-6 and interleukin-18 in the observation group were lower than those in the control group (P<0.05).Conclusion:Metformin combined with Rosuvastatin is more effective than S
作者
汤映
陆伟亮
TANG Ying;LU Weiliang(Yunfu Hospital of Traditional Chinese Medicine,Yunfu 527300,China)
出处
《中外医学研究》
2022年第3期34-37,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
糖尿病
高脂血症
瑞舒伐他汀
辛伐他汀
血糖
Diabetes mellitus
Hyperlipidemia
Rosuvastatin
Simvastatin
Blood glucose
