摘要
目的探讨马来酸噻吗洛尔应用时间对高度近视患者屈光程度的影响。方法选取于本院接受治疗的138例高度近视患者为研究对象,患者均接受准分子激光角膜原位磨镶术(LASIK),在术后应用马来酸噻吗洛尔进行治疗,按照该药物应用时间进行分组,研究组患者在术后第1天开始应用马来酸噻吗洛尔,对照组患者在术后第8天开始应用马来酸噻吗洛尔。检测并比较两组患者手术前后裸眼视力、眼压、屈光度水平及角膜相关指标。结果与术前相比,术后6个月两组患者UCVA、SE水平均显著下降,研究组患者UCVA水平显著低于对照组,SE水平显著高于对照组(P<0.01)。与术前相比,术后6个月两组患者角膜表面曲率、CCT水平均显著下降,但术后6个月两组间无显著差异(P>0.05);与术前相比,术后6个月两组患者眼压水平及研究组Diff值水平均显著下降,且研究组均显著低于对照组(P<0.05或P<0.01)。结论马来酸噻吗洛尔应用时间的延长可显著改善高度近视患者术后屈光程度,更为有效的控制患者眼压水平,调节角膜相关指标,促进患者康复。
Objective To investigate the effect of timolol maleate on refractive index in patients with high myopia.Methods A total of 138 patients with high myopia who were treated in our hospital received excimer laser keratoplasty(LASIK),and were treated with timolol maleate after treatment,the patients in the study group began to use thiomol maleate on the first d after operation,and the control group began to use thiomol maleate on the 8th d after operation.The visual acuity,intraocular pressure,diopter level and corneal correlation index of naked eye before and after operation were measured and compared in 2 groups.Results The UCVA,SE level of the patients in the study group was significantly lower than that in the control group and the SE level was significantly higher than that in the control group(P<0.01).Compared with pre-operation,corneal surface curvature and CCT level decreased significantly in 2 groups 6 months after operation,but there was no significant difference between 2 groups 6 months after operation(P>0.05);Compared with the pre-intraocular pressure level and the Diff value of the study group decreased significantly in the 2 groups 6 months after operation,and the study group was significantly lower than the control group(P<0.05 or P<0.01).Conclusion The prolonged application time of timolol maleate can significantly improve the refractive degree of patients with high myopia,control the intraocular pressure level of patients more effectively,regulate corneal related indexes,and promote the recovery of patients.
作者
郭晶晶
GUO Jing-jing(Department of Eye,Ear,Nose,and Throat,the 83rd Group Army Hospital of the PLA,Xinxiang 453000,Henan Province,China)
出处
《罕少疾病杂志》
2022年第3期16-18,共3页
Journal of Rare and Uncommon Diseases
