摘要
目的:分析黏蛋白1(MUC1)、Ki67在肝内胆管细胞癌(ICC)组织中的表达,探讨MUC1、Ki67的表达与ICC患者临床病理特征及预后的关系。方法:回顾性分析2013年1月至2020年3月在河南省人民医院就诊的398例ICC患者资料。最终104例患者纳入本研究,其中男性67例,女性37例,年龄(56.6±9.3)岁。采用免疫组化检测癌组织中MUC1、Ki67蛋白的表达。单因素以及多因素Cox回归分析ICC患者预后影响因素。结果:65例患者MUC1低表达,39例MUC1高表达。52例患者Ki67低表达,52例Ki67高表达。MUC1高表达与淋巴结转移相关(P<0.05),而Ki67高表达与肿瘤数目、淋巴结转移、血管侵犯相关(均P<0.05)。多因素分析,MUC1高表达(HR=2.321,95%CI:1.420~3.792,P<0.001)、Ki67高表达(HR=2.012,95%CI:1.247~3.247,P=0.004)的ICC患者肝切除术后生存预后较差。MUC1高表达(HR=1.664,95%CI:1.058~2.618,P=0.028)、Ki67高表达(HR=1.883,95%CI:1.168~3.035,P=0.009)的ICC患者肝切除术后无瘤生存预后较差。结论:MUC1、Ki67的高表达与肿瘤的增殖、转移相关。MUC1、Ki67高表达是ICC患者肝切除术后总体生存和无瘤生存的独立危险因素。
Objective To analyze the expression of mucin 1(MUC1)and Ki67 in intrahepatic cholangiocarcinoma(ICC),and to explore the correlations between the expression of MUC1 and Ki67 and the clinicopathological features and prognosis of ICC patients.Methods Clinical data of 398 patients with ICC admitted to Henan Provincial People's Hospital from January 2013 to March 2020 were retrospectively analyzed.A total of 104 patients were included in this study,including 67 males and 37 females,aged(56.6±9.3)years.Immunohistochemistry was used to detect the expression of MUC1 and Ki67 in cancer tissues.Univariate and multivariate Cox regression analysis were used to study the prognostic factors of ICC patients.Results The expression of MUC1 was low in 65 patients and high in 39 patients.Ki67 expression was low in 52 patients and high in 52 patients.High expression of MUC1 was correlated with lymph node metastasis(P<0.05),while high expression of Ki67 was correlated with tumor nodes number,lymph node metastasis and vascular invasion(all P<0.05).Multivariate analysis showed that ICC patients with high MUC1 expression(HR=2.321,95%CI:1.420-3.792,P<0.001)and high Ki67 expression(HR=2.012,95%CI:1.247-3.247,P=0.004)showed a poor prognosis after hepatectomy.ICC patients with high MUC1 expression(HR=1.664,95%CI:1.058-2.618,P=0.028)and high Ki67 expression(HR=1.883,95%CI:1.168-3.035,P=0.009)had a poor prognosis after hepatectomy.Conclusion High expression of MUC1 and Ki67 is correlated with tumor growth and metastasis.MUC1 and Ki67 are independent risk factors for prognosis of ICC patients after hepatectomy.
作者
强泽远
金帅
严操
李真
宁培钢
余海波
Qiang Zeyuan;Jin Shuai;Yan Cao;Li Zhen;Ning Peigang;Yu Haibo(Department of Hepatobiliary Pancreatic Surgery,Henan University People’s Hospital,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Pathology,Henan University People’s Hospital,Henan Provincial People’s Hospital,Zhengzhou 450003,China;Department of Imaging,Henan University People’s Hospital,Henan Provincial People’s Hospital,Zhengzhou 450003,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2022年第1期33-38,共6页
Chinese Journal of Hepatobiliary Surgery
基金
河南省医学重点科技攻关项目(201502018)。
