摘要
目的:探讨不同剂量右美托咪定在老年全麻腹部手术患者中的应用。方法:回顾性分析2018年4月-2020年6月江门市中心医院收治的140例行全麻腹部手术的老年患者的临床资料,根据不同剂量右美托咪定分为低剂量组(n=70)和高剂量组(n=70),在麻醉诱导前,低、高剂量组分别给予0.6、1.0μg/kg右美托咪定静脉泵注,10 min内缓慢泵注完毕,随后两组均继续静脉泵注0.1μg/(kg·h)右美托咪定直至手术结束时停止。记录两组诱导麻醉前(T_(1))、泵入右美托咪定10 min(T_(2))、停用右美托咪定(T_(3))、拔管后10 min(T_(4))血氧饱和度、心率、平均动脉压、Ramsay评分,比较两组不良反应发生率。结果:两组T_(1)、T_(2)、T_(3)、T_(4)时血氧饱和度、心率、平均动脉压、Ramsay评分比较,差异均无统计学意义(P>0.05)。两组T_(2)、T_(3)、T_(4)时血氧饱和度、心率、平均动脉压较T_(1)时均降低(P<0.05),两组T_(2)、T_(3)、T_(4)时Ramsay评分较T_(1)时均升高(P<0.05)。低剂量组不良反应发生率为15.71%,低于高剂量组的30.00%(P<0.05)。结论:低剂量右美托咪定与高剂量右美托咪定在老年全麻腹部手术患者中的麻醉及镇静效果相当,但低剂量右美托咪定的安全性更高。
Objective:To investigate the application of different doses of Dexmedetomidine in elderly patients undergoing abdominal surgery under general anesthesia.Method:The clinical data of 140 elderly patients undergoing abdominal surgery under general anesthesia treated in Jiangmen Central Hospital from April 2018 to June 2020 were retrospectively analyzed.According to different doses of Dexmedetomidine,they were divided into low-dose group(n=70)and high-dose group(n=70).Before anesthesia induction,the low-dose group and high-dose group were given 0.6 and 1.0μg/kg Dexmedetomidine respectively by intravenous pump injection,and the pump injection was completed slowly within 10 min,and then the two groups continued to inject 0.1μg/(kg·h)Dexmedetomidine until the end of operation.The blood oxygen saturation,heart rate,mean arterial pressure and Ramsay score were recorded before anesthesia induction(T;),Dexmedetomidine 10 min after pumping(T;),discontinuation of Dexmedetomidine(T;),and 10 min after extubation(T;).The incidence of adverse reactions was compared between the two groups.Result:There were no significant differences in the blood oxygen saturation,heart rate,mean arterial pressure and Ramsay scores at T;,T;,T;and T;between the two groups(P>0.05).Blood oxygen saturation,heart rate and mean arterial pressure in the two groups at T;,T;and T;were lower than those at T;(P<0.05),Ramsay scores at T;,T;and T;in both groups were higher than those at T;(P<0.05).The incidence of adverse reactions in low-dose group was 15.71%,which was lower than 30.00%in high-dose group(P<0.05).Conclusion:The anesthetic and sedative effects of low-dose Dexmedetomidine and high-dose Dexmedetomidine in elderly patients undergoing abdominal surgery under general anesthesia are similar,but the safety of low-dose Dexmedetomidine is higher.
作者
邓世杰
钟其澎
王成志
DENG Shijie;ZHONG Qipeng;WANG Chengzhi(Jiangmen Central Hospital,Jiangmen 529000,China)
出处
《中外医学研究》
2022年第1期71-74,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广东省江门市科技计划项目(2020YLA026)。
关键词
腹部手术
麻醉
右美托咪定
不同剂量
老年
Abdominal surgery
Anesthesia
Dexmedetomidine
Different doses
Elderly
