摘要
目的:研究分析直肠癌腹腔镜根治术(LRR)的临床疗效,观察其对患者血清炎症因子和氧化应激反应的影响。方法:选取2019年7月1日-2020年12月31日中国医科大学附属盛京医院沈阳雍森医院诊治的166例直肠癌患者为研究对象,依据随机数字表法,将研究对象分为A组和B组,每组83例。A组采用LRR治疗,B组采用传统开腹手术治疗。对比分析两组治疗总有效率、治疗前后各项血清炎症因子变化、氧化应激反应和并发症发生率。结果:A组的临床治疗总有效率高于B组(P<0.05)。术前,两组血清炎症因子水平比较,差异无统计学意义(P>0.05);术后3 d,A组的肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)和C反应蛋白(CRP)水平均低于B组(P<0.05)。术前,两组的氧化应激反应指标比较,差异无统计学意义(P>0.05);术后3 d,A组的丙二醛(MDA)低于B组,而超氧化物歧化酶(SOD)高于B组(P<0.05)。A组的并发症发生率低于B组(P<0.05)。结论:LRR的临床疗效显著,有效减轻炎症因子,缓解氧化应激反应,降低并发症发生率。
Objective:To study and analyze the clinical efficacy of laparoscopic radical resection(LRR)for rectal cancer,and to observe its influence on serum inflammatory factors and oxidative stress reaction.Method:A total of 166 patients with rectal cancer treated in Shenyang Yongsen Hospital,Shengjing Hospital Affiliated to China Medical University from July 1,2019 to December 31,2020 were selected as the research subjects.According to the random number table method,the research subjects were divided into group A and group B,with 83 cases in each group.Group A was treated with LRR,and group B was treated with traditional laparotomy.The total effective rate,the changes of serum inflammatory factors,oxidative stress reaction and the incidence of complications were compared and analyzed between the two groups.Result:The total effective rate of group A was higher than that of group B(P<0.05).Before operation,there were no significant differences in the levels of serum inflammatory factors between the two groups(P>0.05);3 d after operation,the levels of tumor necrosis factor(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in group A were lower than those in group B(P<0.05).Before operation,there were no significant differences in oxidative stress indexes between the two groups(P>0.05);3 d after operation,malondialdehyde(MDA)in group A was lower than that in group B,while superoxide dismutase(SOD)was higher than that in group B(P<0.05).The incidence of complications in group A was lower than that in group B(P<0.05).Conclusion:The clinical effect of LRR is significant,which can effectively reduce inflammatory factors,relieve oxidative stress reaction and reduce the incidence of complications.
作者
朱恩宇
ZHU Enyu(Shenyang Yongsen Hospital,Shengjing Hospital Affiliated to China Medical University,Shenyang 110000,China)
出处
《中国医学创新》
CAS
2022年第1期57-60,共4页
Medical Innovation of China
关键词
腹腔镜根治术
直肠癌
血清炎症因子
氧化应激反应
Laparoscopic radical resection
Rectal cancer
Serum inflammatory factors
Oxidative stress reaction
