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心肌缺血再灌注无复流风险评估的研究进展 被引量:2

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摘要 冠心病(CHD)的病理基础是冠状动脉粥样硬化,其发病率逐年增长且呈年轻化特点,具有病死率与病残率高的特点[1-2]。急性心肌梗死(AMI)是CHD最严重的临床表现类型,可导致急性心肌缺血性坏死甚至猝死。经皮冠状动脉介入治疗(PCI)是AMI最有效的再灌注治疗措施,是有效减少心肌梗死面积,改善心室功能和临床结局的关键因素。然而,PCI即使及时开通心外膜梗死相关的冠状动脉,但缺血心肌有时仍不能得到有效的血流灌注,这被称为无复流(NR)[3]。PCI即使没有残留的心外膜冠脉狭窄,由于NR现象,血运重建并非总是能重建有效的冠脉微循环灌注,女性更常见[4],对梗死面积与心室重构的影响尤为显著,且严重影响PCI术后患者的长远预后[5-6]。NR现象起始于心肌缺血期,恶化于再灌注期,其病理生理基础是冠脉微循环功能障碍(CMD),临床上需更加重视对NR的危险识别与风险评估。本文就近年来对NR的危险因素与风险预测的研究进展进行综述。
出处 《吉林医学》 CAS 2022年第1期239-242,共4页 Jilin Medical Journal
基金 国家自然科学基金项目[项目编号:81860797] 右江民族医学院附属医院高层次人才科研项目[项目编号:Y20196318]。
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