摘要
目的:探讨在老年脑梗死(CI)患者中使用血栓通胶囊联合注射用血塞通的影响。方法:选取2018年1月-2021年1月在延安市博爱医院接受治疗的110例老年CI患者作为研究对象,根据随机数字表法分为观察组(n=55)与对照组(n=55),对照组使用依达拉奉治疗,观察组使用血栓通胶囊联合注射用血塞通治疗,对两组神经功能、炎性因子水平、凝血功能及运动功能进行比较。结果:两组治疗后美国国立卫生研究院卒中量表(NIHSS)评分明显较治疗前降低(P<0.05),治疗后,观察组NIHSS评分较对照组明显更低(P<0.05);两组治疗后超敏C反应蛋白(hs-CRP)、血清纤维蛋白原(FIB)、基质金属蛋白酶-9(MMP-9)水平均较治疗前明显下降(P<0.05),治疗后,观察组hs-CRP、FIB、MMP-9水平均较对照组明显更低(P<0.05);两组治疗后D-二聚体(D-D)水平较治疗前明显下降(P<0.05),观察组治疗后D-D水平明显低于对照组(P<0.05),两组治疗后凝血酶时间(TT)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)较治疗前明显增加(P<0.05),观察组治疗后TT、PT、APTT明显长于对照组(P<0.05);两组治疗后下肢及上肢功能评分较治疗前明显提高(P<0.05),观察组治疗后下肢及上肢功能评分较对照组明显更高(P<0.05)。结论:将血栓通胶囊联合注射用血塞通应用于老年CI患者中可提高神经功能与运动功能,降低炎性因子水平,有效改善凝血功能。
Objective:To investigate the effect of Xueshuantong Capsule combined with Xuesaitong for Injection in elderly patients with cerebral infarction(CI).Method:A total of 110 elderly CI patients who were treated in Bo’ai Hospital of Yan’an City from January 2018 to January 2021 were selected as the research objects.According to the random number table method,they were divided into the observation group(n=55)and the control group(n=55),the control group was treated with Edaravone,and the observation group was treated with Xueshuantong Capsule combined with Xuesaitong for Injection.The nerve function,inflammatory factor level,blood coagulation function and motor function of the two groups were compared.Result:After treatment,the scores of the National Institutes of Health stroke scale(NIHSS)of the two groups were significantly lower than those before treatment(P<0.05),and the NIHSS score of the observation group was significantly lower than that of the control group(P<0.05);after treatment,hypersensitive C-reactive protein(hs-CRP),serum fibrinogen(FIB),and matrix metalloproteinase-9(MMP-9)levels in the two groups were significantly lower than before treatment(P<0.05),and the hs-CRP,FIB,MMP-9 levels after treatment in the observation group were significantly lower than those in the control group(P<0.05);after treatment,the levels of D-dimer(D-D)in the two groups were significantly lower than before treatment(P<0.05),the level of D-D in the observation group was significantly lower than that in the control group(P<0.05),after treatment,thrombin time(TT),plasma prothrombin time(PT)and activated partial thromboplastin time(APTT)in the two groups were significantly higher than before treatment(P<0.05),and the TT,PT,APTT in the observation group were significantly longer than those in the control group(P<0.05);after treatment,the lower limb and upper limb function scores of the two groups were significantly higher than those before treatment(P<0.05),and the lower limb and upper limb function scores of the observation grou
作者
高东阳
GAO Dongyang(Bo’ai Hospital of Yan’an City,Yan’an 716000,China)
出处
《中外医学研究》
2022年第2期25-28,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
血栓通胶囊
注射用血塞通
老年
脑梗死
神经功能
运动功能
Xueshuantong Capsule
Xuesaitong for Injection
Elderly
Cerebral infarction
Nerve function
Motor function
