摘要
库欣综合征(CS)是由于多种病因所致循环血液中糖皮质激素水平持续增高从而产生的一组临床症候群,常包括肥胖、高血压和糖尿病。CS患者长期存在的高糖皮质激素血症对生存率及生存质量影响极大,对疑似CS的患者选择恰当的筛查试验并合理解读试验结果对于CS的诊断至关重要。本文对CS的筛查方法选择及可能影响试验结果的因素进行了分析,并针对国内地塞米松制剂的剂量及国人的体重等因素,提出地塞米松抑制试验需注意的问题。重点强调临床医生应根据患者的具体情况选择恰当的筛查试验。
The clinical features of Cushing's syndrome such as obesity,hypertension,and diabetes are caused by elevated cortisol level.Long-term hyperglycocorticoidemia in patients with Cushing's syndrome(CS)has a great impact on the survival rate and quality of life of patients.Choosing the appropriate screening test for patients with suspected CS and interpreting the test results reasonably is essential for the diagnosis of CS.This article analyzes the selection of screening methods for CS and the factors that may affect the results of the test,and puts forward the issues that should be paid attention to in the dexamethasone suppression test for factors such as the dosage of domestic dexamethasone preparations and the weight of Chinese people.It is emphasized that clinicians should choose the appropriate screening test according to the specific situation of the patient.
作者
李佳琦
孙丽思
余叶蓉
Li Jiaqi;Sun Lisi;Yu Yerong(Department of Endocrinology and Metabolism,West China Hospital of Sichuan University,Chengdu 610041,China)
出处
《国际内分泌代谢杂志》
2021年第6期573-577,共5页
International Journal of Endocrinology and Metabolism
