摘要
严重发热伴血小板减少综合征(SFTS)是一种新发虫媒传染病,由一种引起发热和血小板减少的布尼亚病毒引起。它广泛分布于中国中部和东北部,尤其是农村和丘陵地区,对公众健康构成严重威胁。在此,我们报告了安徽省1例SFTS病例,临床症状为发热、白细胞减少和血小板减少。采用RT-qPCR方法在患者血清、尿液和咽拭子样本中检测到SFTSV。采用RT-PCR法从患者体液中检测到两段病毒互补DNA基因片段并对其进行测序。系统发育分析表明,所获得的序列与中国其他疫区患者的序列相似性较高。这是在同一名患者的血清、咽拭子和尿液中同时检测到发热伴血小板减少综合征布尼亚病毒核酸的首次报道,提示了新型布尼亚病毒存在除蜱虫叮咬以外的接触传播。
Severe fever with Thrombocytopenia Syndrome(SFTS)is an emerging epidemic disease caused by a novel SFTS bunyavirus(SFTSV).It is widely spread in central and northeast of China,particularly in rural and hilly areas,posing a great threat to public health.Here we presented a SFTS case in Anhui Province with clinical symptoms of fever,leukopenia and thrombocytopenia which SFTSV was detected in serum,urine and throat swab samples by RT-qPCR.Two gene fragments of viral complementary DNA were obtained by RT-PCR and sequenced from the patient’s body fluids.Phylogenetic analysis indicated that the sequences obtained were closely related to those from patients in other epidemic areas of China.To our knowledge,it was the first report on the simultaneous detection of SFTSV RNA from serum,throat swabs and urine in the same patient,which suggest to be alert to the possible ways of SFTSV transmission other than tick bite.
作者
艾乐乐
胡丹
朱长强
岳娜
王秋伟
叶福强
吕恒
岳明
谭伟龙
AI Le-Le;HU Dan;ZHU Chang-Qiang;YUE Na;WANG Qiu-Wei;YE Fu-Qiang;LYU Heng;YUE Ming;TAN Wei-Long(Center for Disease Control and Prevention of Eastern Theater Command,Nanjing 210002,Jiangsu,China;Department of Infectious Diseases,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)
出处
《寄生虫与医学昆虫学报》
CAS
2021年第4期237-242,270,共7页
Acta Parasitologica et Medica Entomologica Sinica
基金
Yancheng Municipal Medical Technology Development Project(YK2017119)
National Natural Science Foundation of China(u1602223)
Medical Research Topics of Jiangsu Provincial Health Planning Commission(H2019015,M2020087)
Key Laboratory Opening Project of Guizhou Medical University(GMU-2020-HJ2-005)。
