摘要
目的:探讨沉默信息调节因子1(SIRT1)在结肠腺癌及癌旁组织中的表达,分析其与临床病理特征的关系。方法:收集结肠腺癌及癌旁组织58例,采用免疫组化染色方法观察SIRT1在结肠腺癌及癌旁组织中的表达。结果:SIRT1在结肠腺癌及癌旁组织中的阳性表达率分别为43.1%和7.4%,差异有统计学意义(P<0.05),在结肠腺癌中的表达与肿瘤分化程度和年龄有关(P<0.05)。另外,SIRT1表达部位与肿瘤细胞分化程度有关。结论:SIRT1在结肠腺癌中的阳性表达率和表达部位与肿瘤分化有关,提示SIRT1在结肠腺癌中的高表达可作为预后预测指标。
Objective To investigate the expression of silencing information regulator 1(silent information regulator 1,SIRT1)in adenocarcinoma of colon and adjacent tissues,and to analyze their relationship with clinicopathological features.Method 58 cases of paraffin embedded cancer tissues and adjacent tissues were collected.Routine HE staining and immunohisto-chemical method were used to detect the expression of SIRT1 in both cancer tissues and adjacent tissues.Results The positive expression rates of SIRT1 in adenocarcinoma of colon and adjacent tissues were 43.1%and 7.4%,respectively(P<0.05).SIRT1 expression in adenocarcinoma of colon was associated with tumor differentiation and age(P<0.05).Furthermore,SIRT1 expression sites were associated with differentiation of tumor cells.Conclusion The expression of SIRT1 positive rate and the site in adenocarcinoma of colon are related to malignant degree,these results suggest that high expression of SIRT1 in adenocarcinoma of colon may be a prognostic marker.
作者
张美兰
金仁顺
肖斌
张璇
张学武
ZHANG Mei-lan;JIN Ren-shun;XIAO Bin(Pathology department,Affiliated Hospital of Yanbian University,Yanji 133000,China;College of Medicine,Yanbian University,Yanji 133000,China)
出处
《吉林医学》
CAS
2022年第2期303-305,共3页
Jilin Medical Journal
