摘要
急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)是继发于肺内或全身的炎症反应过程,它由肺泡损伤导致并形成炎症性非心源性的肺水肿。模式识别受体(PRRs)参与先天免疫系统的激活,PRRs可以启动炎症信号级联反应,并释放促炎细胞因子。本综述对PRRs所包括的跨膜受体TLRs、胞质受体RLRs和NLRs以及下游炎症通路NF-κB、IRF、MAPK、NETs、RAGE和Nrf2信号通路及自噬进行总结,以阐述模式识别受体PRRs在ALI/ARDS发病机制中的作用。
Acute lung injury(ALI)/Acute respiratory distress syndrome(ARDS)is an inflammatory reaction process secondary to the lungs or the whole body caused by alveolar injury and forms inflammatory noncardiogenic Pulmonary edema. Pattern recognition receptors(PRRs)are involved in the activation of the innate immune system. PRRs can initiate a cascade of inflammatory signals and release pro-inflammatory cytokines. The review summarizes the role of PRRs in the pathogenesis of ALI/ARDS by including transmembrane receptors TLRs,cytoplasmic receptors RLRs and NLRs,and downstream inflammatory pathways NF-κB,IRF,MAPK and Nrf2 signaling pathways and autophagy.
作者
刁一芮
丁奇
史渊源(指导)
DIAO Yirui;DING Qi;SHI Yuanyuan(Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2022年第2期227-233,共7页
Chinese Journal of Immunology
基金
国家重点研发计划(2019YFC1710105)资助。
关键词
急性肺损伤
急性呼吸窘迫综合征
模式识别受体
发病机制
Acute lung injury
Acute respiratory distress syndrome
Pattern recognition receptors
Pathogenesis
