摘要
目的观察常规西药治疗、常规西药+化浊解毒方口服、常规西药+化浊解毒方+耳穴贴压治疗小儿急性化脓性扁桃体炎疗效差异并探讨其作用机制。方法患者129例随机分为对照1组、对照2组及观察组,对照1组接受西医常规治疗;对照2组在对照1组基础上接受化浊解毒方口服;观察组在对照2组基础上接受耳穴贴压治疗。观察发热、咽痛、扁桃体肿大、脓性分泌物消退时间;观察治疗前后中医症状积分;检测治疗前后血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和血常规中的白细胞(WBC)水平变化,并统计临床疗效。结果观察组在发热、咽痛、扁桃体肿大、脓性分泌物消退时间短于对照1组、对照2组(P<0.05),且对照2组优于对照1组(P<0.05)。各组在中医症状各项积分方面明显低于同组治疗前(P<0.05);治疗后观察组在中医症状各项积分方面分别低于对照1组、对照2组(P<0.05),且对照2组优于对照1组(P<0.05)。3组在hs-CRP、TNF-α、IL-6、IL-8、WBC计数方面明显低于同组治疗前(P<0.05);治疗后观察组在hs-CRP、TNF-α、IL-6、IL-8、WBC计数方面分别低于对照1组、对照2组(P<0.05),且对照2组优于对照1组(P<0.05)。观察组临床疗效总有效率95.12%分别优于对照1组77.50%、对照2组87.50%(P<0.05),且对照2组优于对照1组(P<0.05)。结论在常规应用西药的基础上化浊解毒方联合耳穴贴压治疗小儿急性化脓性扁桃体炎疗效确切,可有效改善发热、咽痛、扁桃体肿大、脓性分泌物及中医症状,可有效调节hs-CRP、TNF-α、IL-6、IL-8、WBC计数水平。
Objective:To observe the clinical efficacy and difference of conventional western medicine treatment,conventional western medicine combined with Huazhuo Jiedu Decoction and conventional western medicine based Huazhuo Jiedu Decoction combined with auricular plaster therapy in the treatment of children with acute suppurative tonsillitis.Methods:A total of 129 children with acute suppurative tonsillitis were randomly divided into control group 1,control group 2 and observation group,43 cases in each group.Control group 1 received conventional western medicine treatment;control group 2 received Huazhuo Jiedu Decoction on the basis of control group 1;the observation group received auricular plaster therapy on the basis of the control group 2.The regression time of fever,sore throat,tonsillema and purulent secretion was observed;TCM symptom scores were observed before and after treatment;Serum hs-CRP and TNF-αwere detected before and after treatment;the levels of interleukin-6(IL-6),interleukin-8(IL-8)and white blood cell(WBC)in blood routine were measured.Results:The observation group in fever,sore throat,tonsillar enlargement,purulent secretion regression time were compared with the control group 1 and the control group 2,the differences were statistically significant(P<0.05),and control group 2 was better than control group 1(P<0.05).The scores of TCM symptoms in the three groups were significantly lower than those before treatment in the same group(P<0.05).After treatment,the observation group in TCM symptom score,hs-CRP,TNF-α,IL-6,IL-8,WBC count were lower than control group 1 and control group2,the differences were statistically significant(P<0.05),and control group 2 was better than control group 1(P<0.05).The total effective rate was 95.12%in the observation group,77.50%in control group 1 and 87.50%(35/40)in control group 2.The total effective rate of the observation group was better than that of the control group 1 and the control group 2(P<0.05),and the control group 2 was better than that of the control gr
作者
孙波
董书桂
刘伟然
杜美容
王巍
孙映雪
Sun Bo;Dong Shugui;Liu Weiran;Du Meirong;Wang Wei;Sun Yingxue(Tangshan Maternal and Child Health Care Hospital,Hebei,Tangshan 063000,China)
出处
《中国中医急症》
2022年第1期115-118,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
河北省中医药管理局中医药类科研计划课题(2020416)。
关键词
小儿
急性化脓性扁桃体炎
浊毒理论
耳穴贴压
化浊解毒方
炎症因子
Children
Acute suppurative tonsillitis
Turbid toxin theory
Auricular plaster therapy
Huazhuo Jiedu Decoction
Inflammatory factors
