摘要
目的研究酒石酸美托洛尔联合贝那普利对高血压(EH)合并心力衰竭(FH)患者心功能指标、血压昼夜节律变化及心率变异性的影响。方法将高血压合并心力衰竭患者144例随机均分为贝那普利组(贝那普利治疗)和联合组(酒石酸美托洛尔联合贝那普利治疗)。比较两组治疗前后心功能指标、血压昼夜节律变化、心率变异性,并用Logistic回归分析其影响因素。结果治疗后两组心功能指标、血压昼夜节律变化和心率变异性指标较治疗前均明显改善,且联合组较贝那普利组改善更为显著(P<0.05)。影响两药联合治疗效果的因素有年龄、NYHA分级、冠心病、瓣膜病、左心室射血分数、肺部啰音、心律失常、脑钠肽治疗、肺动脉高压。结论酒石酸美托洛尔联合贝那普利治疗高血压合并心力衰竭疗效显著,有助于提高患者心功能,改善血压昼夜节律变化和心率变异性,预后安全,具有临床推广应用价值。
Aim To study the effects of metoprolol tartrate combined with benazepril on cardiac function,circa-dian rhythm and heart rate variability in patients with essential hypertension(EH)and heart failure(FH).Methods One hundred and forty-four patients with hypertension complicated with heart failure were randomly divided into benazeprilgroup(treated with benazepril)and combined group(treated with metoprolol tartrate combined with benazepril).Cardiacfunction,circadian rhythm,and heart rate variability were compared between the two groups before and after treatment,andthe influencing factors were analyzed by Logistic regression.Results After treatment,the indexes of cardiac function,blood pressure circadian rhythm and heart rate variability were significantly improved in both groups,and the improvementin the combined group was more significant than that in the benazepril group(P<0.05).The factors influencing the effi-cacy of the combination therapy were age,NYHA grade,coronary heart disease,valvular disease,left ventricular ejectionfraction,pulmonary rales,arrhythmia,brain natriuretic peptide therapy and pulmonary hypertension.Conclusion Metoprolol tartrate combined with benazepril in the treatment of hypertension complicated with heart failure has a significanteffect,which is helpful to improve the heart function of patients,improve the circadian rhythm and heart rate variability,and has a safe prognosis and clinical application value.
作者
时彬
卢运
魏晶晶
SHI Bin;LU Yun;WEI Jingjing(Cardiovascular Department,the First Peoples Hospital of Huaian,Huaian,Jiangsu 223002,China)
出处
《中南医学科学杂志》
CAS
2022年第1期93-97,共5页
Medical Science Journal of Central South China
关键词
酒石酸美托洛尔
高血压合并心力衰竭
心功能
血压昼夜节律变化
心率变异性
metoprolol tartrate
hypertension complicated with heart failure
cardiac function
circadian rhythm change
heart rate variability
