摘要
In general,acute myeloid leukemia(AML)is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality.One of the mutations related to AML is the Flt3-ITD mutation,which is found in approximately 25%of patients.In this mini-review,we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality.Finally,we discuss some AML therapeutic strategies,including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.
