摘要
脂质代谢重编程是许多恶性肿瘤的重要特征,其代谢重编程过程主要包括以下几个方面,首先是脂肪酸从头合成增强及脂肪酸氧化之间的动态平衡;其次是肿瘤中生物膜脂质成分发生变化以适应其增殖需求;另外,肿瘤中的脂质信号分子改变可以促进肿瘤进展,肿瘤中脂代谢相关蛋白表达上调促进肿瘤的恶性表型的发生。本文将综述肿瘤细胞脂代谢涉及的各个环节及其特征,为肿瘤的诊断治疗及预后评估寻找新的靶点。
Lipid metabolic reprogramming is an important feature of many malignant tumors.Its metabolic reprogramming process mainly includes the following aspects.Firstly,the dynamic balance between the enhancement of de novo synthesis of fatty acids and the oxidation of fatty acids;Secondly,the lipid composition of biological membrane in tumor was changed to adapt to the tumor proliferation.In addition,changes in lipid signaling molecules in tumors can promote tumor progression,up-regulation of lipid metabolism-related protein in tumors can pronote the occurrence of malignant tumor phenotypes.In this review,we will focus on the aspects and characteristics of lipid metabolism in tumor cells to find new targets for diagnosis,treatment and prognosis assessment of tumors.
作者
赵丽
彭瑞
朱明雪
王晔(综述)
牟晓峰(审校)
ZHAO Li;PENG Rui;ZHU Mingxue;WANG Ye;MU Xiaofeng(Medical College of Qingdao University,Qingdao,Shandong 266003,China;Department of Clinical Laboratory,Qingdao Central Hospital,Qingdao,Shandong 266042,China)
出处
《国际检验医学杂志》
CAS
2022年第3期367-370,384,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81670822、81370990)
青岛市医疗卫生重点学科建设项目(青卫科教字[2019]9号)。
关键词
脂代谢重编程
脂肪酸从头合成
脂肪酸氧化
脂质信号分子
lipid metabolism reprogreamming
de novo fatty acid synthesis
fatty acids oxidation
lipid signaling molecules
