摘要
目的分析醒脑开窍针刺法联合多感觉刺激对脑卒中后吞咽障碍患者吞咽功能、神经功能、神经生长因子(NGF)及脑源性神经营养因子(BDNF)水平的影响。方法前瞻性将2019年1月至2020年1月陕西省中医医院收治的96例脑卒中后吞咽障碍患者纳入研究,依照数字随机表法将其分为对照组(n=48)与观察组(n=48),其中对照组给予常规干预,观察组则行醒脑开窍针刺法联合多感觉刺激干预。比较两组患者干预前及干预3个月后的美国国立卫生研究院卒中量表(NIHSS)评分、Fugl-Meyer评分、NGF及BDNF水平和吞咽功能治疗疗效。结果观察组患者吞咽功能治疗总有效率为91.49%,显著高于对照组(70.21%),差异有统计学意义(P<0.05)。干预3个月后,两组NIHSS评分均较干预前显著下降,且观察组NIHSS评分为(4.53±1.53)分,低于对照组[(8.58±1.86)分],差异均有统计学意义(P<0.05)。干预3个月后,两组患者的运动功能评分、NGF及BDNF水平均较干预前显著升高,且观察组患者的运动功能评分、NGF及BDNF水平分别为(60.39±16.41)分、(67.95±9.12)pg/mL、(7.71±0.89)ng/mL,均高于对照组[(54.32±13.53)分、(55.63±6.52)pg/mL、(5.58±0.73)ng/mL],差异均有统计学意义(P<0.05)。结论醒脑开窍针刺法联合多感觉刺激可有效改善脑卒中后吞咽障碍患者吞咽功能、神经功能、神经营养因子水平,值得推广和应用。
Objective To analyze the effects of Xingnao Kaiqiao Acupuncture combined with multisensory stimulation on swallowing function,neurological function and the levels of nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)in patients with dysphagia after stroke.Methods A total of 96 patients with dysphagia after stroke treated in Shaanxi Provincial Hospital of Traditional Chinese Medicine from January 2019 to January 2020 were prospectively included in this study.According to the method of digital random table,they were divided into control group(n=48)and observation group(n=48).The control group was given routine intervention,and the observation group was given Xingnaokaiqiao Acupuncture combined with multisensory stimulation intervention.National Institute of Health stroke scale(NIHSS)score,Fugl Meyer score,levels of NGF and BDNF and swallowing function were compared between the two groups before and 3 months after intervention.Results The total effective rate of swallowing function treatment in the observation group was 91.49%,which was significantly higher than that in the control group(70.21%),and the difference was statistically significant(P<0.05).After 3 months of intervention,the NIHSS scores in the two groups were significantly lower than those before the intervention,and the NIHSS scores in the observation group were(4.53±1.53)points,which were lower than those in the control group[(8.58±1.86)points],the differences were statistically significant(P<0.05).After 3 months of intervention,the motor function scores,the levels of NGF and BDNF expression in the two groups of patients were significantly higher than those before the intervention,and the motor function scores,the levels of NGF and BDNF expression in the observation group were(60.39±16.41)points,(67.95±9.12)pg/mL,(7.71±0.89)ng/mL,respectively,which were higher than those in the control group[(54.32±13.53)points,(55.63±6.52)pg/mL,(5.58±0.73)ng/mL],the differences were statistically significant(P<0.05).Conclusion Xingnao Kaiqiao
作者
罗琼
王博毅
曹妍杰
LUO Qiong;WANG Bo-yi;CAO Yan-jie(Department of Acupuncture and Moxibustion,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi'an Shaanxi 710000,China)
出处
《临床和实验医学杂志》
2022年第2期211-215,共5页
Journal of Clinical and Experimental Medicine
基金
陕西省科学技术厅(编号:2018SF-298)。
关键词
脑卒中
醒脑开窍针刺
冰刺激
吞咽功能
神经功能缺损
Stroke
Xingnao Kaiqiao Acupuncture
Ice stimulation
Swallowing function
Neural function defect
