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分化型甲状腺癌远处转移的相关危险因素分析 被引量:1

Analysis of risk factors for distant metastasis of differentiated thyroid cancer
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摘要 目的探讨分化型甲状腺癌(DTC)远处转移的相关危险因素。方法回顾性分析1998年1月至2018年12月行手术治疗的9201例甲状腺癌患者的病历资料,所有患者手术后病理结果均为分化型甲状腺癌,其中发生远处转移37例,以4∶1的比例随机抽取术后无远处转移的患者148例作为对照组。采用χ2、Student′s t检验及Logistic回归分别行单因素和多因素分析,探讨影响DTC远处转移的危险因素。结果单因素分析显示,患者年龄、肿瘤直径、症状、手术方式、组织学类型、甲状腺外侵犯、AJCC分期及肿瘤位置比较,差异有统计学意义(P<0.05),其余因素均无统计学意义(P>0.05);多因素Logistic回归分析结果显示,患者年龄、肿瘤直径、组织学类型、多灶性、甲状腺外侵犯和AJCC分期是独立的危险因素,即与远处转移显著相关。结论患者年龄、肿瘤直径、组织学类型、多灶性、甲状腺外侵犯和AJCC分期是DTC远处转移的确切危险因素。 Objective To investigate the risk factors for distant metastasis of differentiated thyroid cancer(DTC).Methods A retrospective analysis of the medical records of 9201 patients with thyroid cancer who underwent surgical treatment from January 1998 to December 2018 was conducted.The pathological results of all patients after surgery showed differentiated thyroid cancer.Among them,37 patients had distant metastases.The 148 patients without distant metastases after operation were randomly selected at a ratio of 4:1 as the control group.χ2 Student′s t test and Logistic regression were used to perform univariate-and multivariate analyses to explore the risk factors for distant metastasis of DTC.Results Univariate analysis showed that age,tumor diameter,symptoms,surgical methods,histological type,extrathyroidal invasion,AJCC staging,and tumor location were statistically significant(P<0.05),and the other factors were not statistically significant(P>0.05).Multivariate Logistic regression analysis showed that age,tumor diameter,histological type,multifocality,extrathyroidal invasion and AJCC staging were independent risk factors,which were significantly related to distant metastasis.Conclusion Patient age,tumor diameter,histological type,multifocality,extrathyroidal invasion and AJCC staging are the exact risk factors for distant metastasis of DTC.
作者 王振栋 冯培 黄九平 杨沛沛 钱林学 WANG Zhendong;FENG Pei;HUANG Jiuping;YANG Peipei;QIAN Linxue(Department of Ultrasound,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Interventional Ultrasound,First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Department of Radiological Diagnostics,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China;Department of Ultrasound,Peking University Third Hospital,Beijing 100083,China)
出处 《中国现代医生》 2021年第36期1-4,8,共5页 China Modern Doctor
基金 北京市医院管理局“登峰”人才培养计划项目(DFL20180102)。
关键词 分化型甲状腺癌 术后 远处转移 危险因素 Differentiated thyroid cancer Postoperative Distant metastasis Risk factors
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