摘要
目的对全自动血液成分分离机制备不同容量冷沉淀的质量进行评价。方法抽取长春市中心血站2019年1月至2020年4月采集的400 ml合格血液60袋,按照标准操作规程制备新鲜冰冻血浆,采用全自动血液成分分离机制备冷沉淀凝血因子。按照冷沉淀凝血因子终产品容量分组,将其分为A、B两组,A组:20~30 ml,30袋;B组:40~50 ml,30袋。比较两组冷沉淀的容量、Ⅷ因子含量、纤维蛋白原含量。结果A组的容量[(29.73±0.74)ml/袋]低于B组[(44.57±2.80)ml/袋],差异有统计学意义(P<0.001)。A组的Ⅷ因子含量[(103.78±15.06)U/袋]、纤维蛋白原含量[(289.60±58.72)mg/袋]与B组[(104.68±24.42)U/袋、(296.70±55.29)mg/袋]比较,差异无统计学意义(P>0.05)。结论采用全自动血液成分分离机制备不同容量的冷沉淀,两组冷沉淀的质量无差别,均符合国家标准,此制备方法值得推广。
Objective To evaluate the quality of cryoprecipitation with different volumes prepared by the automatic blood component separator.Methods A total of 60 bags of 400 ml qualified blood collected in Changchun Central Blood Station from January 2019 to April 2020 were selected.Fresh frozen plasma was prepared according to standard operating procedures,and cryoprecipitated coagulation factors were prepared by automatic blood component separator.According to the final product volume of coagulation factor,they were divided into groups A and B,group A:20-30 ml,30 bags;group B:40-50 ml,30 bags.The cryoprecipitate capacity,Ⅷfactor content and fibrinogen content were compared between the two groups.Results The volume of group A([29.73±0.74]ml/bag)was lower than that of group B([44.57±2.80]ml/bag),and the difference was statistically significant(P<0.001).There were no statistically significant differences inⅧfactor content([103.78±15.06]U/bag)and fibrinogen content([289.60±58.72]mg/bag)between group A and group B([104.68±24.42]U/bag,[296.70±55.29]mg/bag)(P>0.05).Conclusion The automatic blood component separator is used to prepare cryoprecipitation with different capacities.There is no difference in the quality of cryoprecipitation between the two groups,which meets the national standards.This preparation method is worth promoting.
作者
王惟
柴婷婷
张雪松
李云强
刘祥君
WANG Wei;CHAI Tingting;ZHANG Xuesong;LI Yunqiang;LIU Xiangjun(Department of Component Preparation,Changchun Central Blood Station,Jilin Province,Changchun130033,China)
出处
《中国当代医药》
CAS
2022年第3期33-36,共4页
China Modern Medicine
基金
吉林省卫生与健康适宜技术推广项目(2020S021)。
