摘要
目的探讨肝胃不和型功能性消化不良患者应用莫沙必利联合柴胡疏肝散的临床效果。方法方便选取2019年6月—2021年6月该院收治的121例肝胃不和型功能性消化不良患者为研究对象,采用随机抛硬币方式对患者予以分组,参照组(60例)的治疗方式为莫沙必利联合米曲菌胰酶片,观察组(61例)的治疗方式为莫沙必利联合柴胡疏肝散,对比分析两组患者临床治疗效果、中医证候积分以及胃肠激素相关指标。结果治疗后,观察组患者临床治疗总有效率(96.7%)与参照组对比,差异有统计学意义(χ^(2)=7.148,P=0.007);观察组患者中医证候积分、胃动素、胃泌素、5-羟色胺以及一氧化氮分别为(5.18±0.71)分、(288.15±22.04)pg/mL、(80.26±3.11)pg/mL、(84.16±7.48)ng/L、(59.38±4.94)μmol/L,均明显优于参照组,差异有统计学意义(t=22.303、7.587、29.148、6.445、10.536,P<0.05)。结论肝胃不和型功能性消化不良患者应用莫沙必利联合柴胡疏肝散可以明显改善患者临床症状和胃肠激素水平,提升临床治疗有效率,对促进患者康复具有积极意义。
Objective To discuss the clinical effect of mosapride combined with Chaihu Shugan powder in patients with liver-stomach discord functional dyspepsia.Methods 121 patients with functional dyspepsia of disharmony between liver and stomach treated in the hospital from June 2019 to June 2021 were conveniently selected as the research object.The patients were randomly divided into groups by coin tossing.The treatment method of the reference group(60 cases)was mosapride combined with aspergillus oryzae pancreatin tablets,and the treatment method of the observation group(61 cases)was mosapride combined with Chaihu Shugan powder.The clinical treatment effect,TCM syndrome score and gastrointestinal hormone related indexes of the two groups were compared and analyzed.Results After treatment,the total effective rate of clinical treatment in the observation group(96.7%)compared with the reference group,and the difference was statistically significant(χ^(2)=7.148,P=0.007).The scores of TCM syndrome,motilin,gastrin,serotonin and nitric oxide in the observation group were(5.18±0.71)points,(288.15±22.04)pg/mL,(80.26±3.11)pg/mL,(84.16±7.48)ng/L,(59.38±4.94)μmol/L,respectively,were obviously better than the reference group,and the difference was statistically significant(t=22.303,7.587,29.148,6.445,10.536,P<0.05).Conclusion The application of mosapride combined with Chaihu Shugan powder in patients with liver-gastric discordant functional dyspepsia can significantly improve the clinical symptoms and gastrointestinal hormone levels of the patients,and improve the effective rate of clinical treatment.It is of positive significance to promote the recovery of patients.
作者
李汝灿
LI Rucan(Funeng Group General Hospital,Fuzhou,Fujian Province,350000 China)
出处
《中外医疗》
2021年第35期147-149,154,共4页
China & Foreign Medical Treatment
关键词
肝胃不和型功能性消化不良
莫沙必利
柴胡疏肝散
中医证候
胃肠激素水平
Liver-gastric discordant functional dyspepsia
Mosapride
Chaihu Shugan Powder
TCM syndromes
Gastrointestinal hormone levels
