摘要
目的观察糖尿病视网膜病变(DR)患眼角膜生物力学特性改变,初步分析其与DR程度的关系。方法回顾性研究。2020年9月至2021年2月于郑州大学第一附属医院眼科治疗的2型糖尿病(T2DM)合并DR患者83例83只眼(DR组)、门诊招募的T2DM不伴DR患者30例30只眼(NDR组)以及非糖尿病患者30例30只眼(NDM组)纳入研究。均选择左眼为研究眼。DR组83只眼中,非增生型DR(NPDR)、增生型DR(PDR)分别为39、44只眼,据此再分为NPDR组、PDR组。DR组、NDR组、NDM组患者间年龄(t=1.10)、性别构成比(χ2=0.46)比较,差异无统计学意义(P>0.05);体重指数(t=3.74)、糖化血红蛋白(t=35.02)、眼轴长度(t=5.51)比较,差异有统计学意义(P<0.05)。采用眼反应分析仪(ORA)测量受检眼角膜滞后量(CH)、角膜阻力因子(CRF)及Goldman相关眼压(IOPg)、角膜代偿眼压(IOPcc)。采用角膜地形图测量受检眼角膜中央厚度(CCT)。多组间CCT、IOPcc、IOPg、CH、CRF的差异比较采用单因素方差分析。采用多元线性回归分析法分析DR患者CH、CRF与其相关影响因素之间的关系。结果DR组、NDR组、NDM组受检眼之间CCT、IOPcc、IOPg、CH、CRF比较,差异均有统计学意义(F=3.71、5.60、9.72、9.02、21.97,P<0.05)。组间两两比较,CH、CRF:DR组与NDM组、NDR组的差异有统计学意义(P<0.05);CCT:DR组与NDM组的差异有统计学意义(P<0.05),与NDR组的差异无统计学意义(P>0.05)。CCT、CH、CRF:NDR组与NDM组的差异无统计学意义(P>0.05)。多元线性回归分析结果显示,DR患者CCT、IOPcc是CH的独立影响因素[CCT:β=0.01,95%可信区间(CI)0.01~0.03,P=0.013;IOPcc:β=-0.15,95%CI-0.25~-0.05,P=0.005];年龄、CCT、IOPcc是CRF的独立影响因素[年龄:β=-0.06,95%CI-0.09~-0.03,P<0.001;CCT:β=0.01,95%CI 0.00~0.02,P=0.049;IOPcc:β=0.16,95%CI 0.07~0.25,P=0.001]。NDR组、NPDR组、PDR组患眼CCT、CH、CRF、调整后CH、调整后CRF比较,差异有统计学意义(F=3.76、5.36、12.61、6.59、10.41,P<0.05)。�
Objective To observe the changes in the biomechanical properties of the cornea of diabetic retinopathy(DR),and analyze its relationship with the degree of DR.Methods A retrospective study.From September 2020 to February 2021,83 patients with type 2 diabetes(T2DM)combined with DR treated in the Department of Ophthalmology,The First Affiliated Hospital of Zhengzhou University,83 eyes(DR group),30 patients with T2DM without DR recruited from the outpatient clinic 30 eyes(NDR group)and 30 eyes of non-diabetes patients(NDM group)were included in the study.All left eyes were chose as the study eye.Among the 83 eyes in the DR group,39 eyes were non-proliferative DR(NPDR)and 44 eyes were proliferative DR(PDR).Based on this,they were divided into NPDR group and PDR group.There was no statistically significant difference in age(t=1.10)and sex ratio(χ2=0.46)among patients in the DR group,NDR group,and NDM group(P>0.05);body mass index(t=3.74),glycosylated hemoglobin(t=35.02)and the length of the eye axis(t=5.51),the difference was statistically significant(P<0.05).The eye response analyzer(ORA)was used to measure the corneal hysteresis(CH),corneal resistance factor(CRF),Goldman related intraocular pressure(IOPg),and corneal compensatory intraocular pressure(IOPcc).The corneal topography was used to measure the central corneal thickness(CCT)of the examined eye.The differences of CCT,IOPcc,IOPg,CH,CRF among multiple groups were compared by one-way analysis of variance.Multiple linear regression was used to analyze the relationship between CH,CRF and related influencing factors in DR patients.Results There were statistically significant differences in CCT,IOPcc,IOPg,CH,and CRF among the eyes of the DR group,NDR group,and NDM group(F=3.71,5.60,9.72,9.02,21.97;P<0.05).Pairwise comparisons were between groups,CH,CRF:the difference between the DR group and the NDM group and the NDR group was statistically significant(P<0.05);CCT:the difference between the DR group and the NDM group was statistically significant(P<0.05),and The di
作者
杜志强
孙靖茹
董怡辰
万光明
Du Zhiqiang;Sun Jingru;Dong Yichen;Wan Guangming(Department of Ophthalmology,The First Affiliated Hospital of Zhengzhou University,Henan Provincial Ophthalmic Hospital,Zhengzhou 450052,China)
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2022年第1期14-19,共6页
Chinese Journal of Ocular Fundus Diseases
基金
国家自然科学基金(面上项目)(81970824)。
