摘要
胞外囊泡(EVs)是不同细胞间及多种组织间信号交流的重要途径,广泛参与组织发育、稳态维持和再生修复等过程。间充质干细胞(MSCs)分泌的EVs含有丰富的生物活性物质,是MSCs发挥促组织再生作用的重要分泌性成分之一。近年来,MSCs分泌的EVs(MSC-EVs)在牙及颌面组织修复再生中的研究取得快速进展。MSC-EVs已被证实可以有效促进牙及颌骨中干细胞和前体细胞的增殖、分化、存活、迁移,并加快血管神经再生,从而可应用于牙髓、牙周、颌骨、颞下颌关节及颌面软组织的再生。因为EVs具备免疫原性低、作用途径广、可规模化制备等优势,其临床应用潜力巨大。随着对EVs作用机理的深入探索和标准化制备及检测体系的建立,MSC-EVs治疗有望成为牙及颌面部组织再生的重要策略。
Extracellular vesicles(EVs)are the essential mediators of communication between different cells or tissues.EVs participate in the development,homeostasis,repair,and regeneration of tissues.Mesenchymal stem cells(MSCs)secrete a range of bioactive factors,which are important in MSC-mediated tissue regeneration.Great progress has been made in the research of EVs derived from MSCs(MSC-EVs)in the regeneration of dental and maxillofacial tissues.Emerging evidence confirmed that MSC-EVs can efficiently modulate the proliferation,differentiation,survival,and migration of stem or progenitor cells and stimulate the regeneration of the neurovascular system.MSC-EVs have been used in regenerating dental pulp,periodontium,jawbone,temporomandibular joint,and maxillofacial soft tissues.Having the advantages of low immunogenicity,versatile function,and suitability for large-scale production,EVs have excellent clinical application prospect.Along with investigations on molecular mechanisms of action and development of standard manufactory and testing systems,therapies using MSC-EVs are promising strategies for regenerating dental and maxillofacial tissues.
作者
廖立
田卫东
Liao Li;Tian Weidong(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Engineering Research Center of Oral Translational Medicine,Ministry of Education&National Engineering Laboratory for Oral Regenerative Medicine&Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2022年第1期7-13,共7页
West China Journal of Stomatology
基金
国家自然科学基金(82071092)
四川省重点研发项目(2019YFS0311,2019YFS0515)。
关键词
胞外囊泡
间充质干细胞
牙
颌骨
再生
extracellular vesicles
mesenchymal stem cells
tooth
jawbone
regeneration
