摘要
目的:比较新型口服抗凝剂利伐沙班与传统口服抗凝剂华法林在左心耳封堵术后患者抗栓治疗方案中的有效性和安全性。方法:选择我院行左心耳封堵术的非瓣膜性房颤患者225例。患者随机纳入华法林组112例和利伐沙班组113例,随访2个月,比较两组患者左心耳封堵器表面血栓形成发生率、左心房血栓形成发生率、缺血性脑卒中、非中枢神经系统性栓塞事件、出血事件及其他不良反应的发生率。结果:与华法林组比较,利伐沙班组患者封堵器表面血栓(0.88%比6.25%)、缺血性脑卒中(0%比3.57%)、皮肤黏膜淤血瘀斑、紫癜(11.50%比33.04%)、颅脑出血(0%比3.57%)及胃肠道异常反应发生率(2.65%比16.92%)明显降低(均P<0.05);其余项目两组之间比较,差异均无统计学意义(P>0.05)。结论:新型口服抗凝药物利伐沙班可能在非瓣膜性房颤患者左心耳封堵术后抗栓效果和安全性优于华法林。
Objective:To compare the efficacy and safety of the new oral anticoagulant Rivaroxaban and the conventional oral anticoagulant Warfarin in the antithrombotic treatment of patients after left atrial appendage occlusion.Methods:A total of 225 patients with non⁃valvular atrial fibrillation,who underwent left atrial appendage occlusion in our hospital,were included in the study.All patients were randomly divided into the Warfarin group(n=112)and the Rivaroxaban group(n=113),and followed up for 2 months.The incidences of thrombus on left atrial appendage occluder surface,left atrial thrombosis,ischemic stroke,non⁃central nerve system embolism events,bleeding events and other adverse reactions in the two groups were compared.Results:Compared with the Warfarin group,the incidences of thrombus on occluder surface(0.88%vs.6.25%),ischemic stroke(0%vs.3.57%),skin mucosal congestion and ecchymosis,purpura(11.50%vs.33.04%),the incidence of cerebral hemorrhage(0%vs.3.57%),and gastrointestinal abnormalities(2.65%vs.16.92%)significantly decreased in the Rivaroxaban group(all P<0.05).There were no statistically significant differences in the other indicators between the two groups(all P>0.05).Conclusion:The new oral anticoagulant Rivaroxaban performed better antithrombotic effect and higher safety than Warfarin after left atrial appendage occlusion in patients with non⁃valvular atrial fibrillation.
作者
陈新敬
吴志勇
郭延松
张胜利
Chen Xinjing;Wu Zhiyong;Guo Yansong;Zhang Shengli(Department of Cardiology,Provincial Clinical Medical College of Fujian Medical University,Fujian Provincial Hospital,Fuzhou,Fujian 350001,China;School of Humanities and Management,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China)
出处
《广州医科大学学报》
2021年第6期64-67,共4页
Academic Journal of Guangzhou Medical University
基金
福建省自然科学基金计划项目(2018J01244)
福建省卫生系统中青年骨干人才培养项目(2017⁃ZQN⁃9)。
关键词
利伐沙班
华法林
左心耳封堵术
卒中
Rivaroxaban
Warfarin
Left atrial appendage occlusion
Stroke
