摘要
组蛋白去甲基化酶KDM7家族包括KDM7A、KDM7B、KDM7C三种蛋白,主要通过去除与转录沉默相关的特定组蛋白赖氨酸甲基化修饰,进而对基因转录发挥调控作用。目前,对KDM7家族的研究主要集中于其在神经分化、肿瘤发生发展等过程中的作用,而对其在脑神经疾病中的作用却知之甚少。本文从该蛋白家族表观遗传调控机制、结构生物学及其在脑神经疾病中的作用等方面进行了综述,以期为研究其在脑神经疾病中的功能机制提供参考,为理解脑神经疾病分子病理机制以及探索基于该机制的有效治疗靶点带来新的启示。
The histone demethylases of KDM7 family,including KDM7 A,KDM7 B and KDM7 C,regulate transcription through acting on specific histone lysines.Previous studies have shown that these family members are functionally important for the processes of neural differentiation and tumor development,and little is known about their roles in brain neurological diseases.In this review,we summarize the latest research progress of KDM7 family on their epigenetic regulation mechanisms,their protein structures and their functions in brain-related diseases,which will likely advance our understanding of the molecular mechanisms of neurological diseases.
作者
杨卓瑾
张玉向
杨茜茜
高菲菲
杨婧思
阎春霞
Zhuojin Yang;Yuxiang Zhang;Xixi Yang;Feifei Gao;Jingsi Yang;Chunxia Yan(College of Forensic Medicine,Xi’an Jiaotong University,Xi’an 710061,China;Key Laboratory of National Health Commission for Forensic Medicine,Xi'an Jiaotong University,Xi'an 710061,China;Bio-evidence Sciences Academy,Western China Science and Technology Innovation Harbor,Xi'an Jiaotong University,Xi'an 712000,China)
出处
《遗传》
CAS
CSCD
北大核心
2022年第1期25-35,共11页
Hereditas（Beijing)
基金
国家自然科学基金项目(编号:81971792,81901920)
中国博士后基金(编号:2019M663746)
陕西省自然科学研究计划项目(编号:2020JQ-091)资助。
