摘要
Biohybrid artificial muscle produced by integrating living muscle cells and their scaffolds with free movement in vivo is promising for advanced biomedical applications,including cell-based microrobotic systems and therapeutic drug delivery systems.Herein,we provide a biohybrid artificial muscle constructed by integrating living muscle cells and their scaffolds,inspired by bundled myofilaments in skeletal muscle.First,a bundled biohybrid artificial muscle was fabricated by the integration of skeletal muscle cells and hydrophilic polyurethane(HPU)/carbon nanotube(CNT)nanofibers into a fiber shape similar to that of natural skeletal muscle.The HPU/CNT nanofibers provided a stretchable basic backbone of the 3-dimensional fiber structure,which is similar to aain-myosin scaffolds.The incorporated skeletal muscle fibers contribute to the actuation of biohybrid artificial muscle.In fact,electrical field stimulation reversibly leads to the contraction of biohybrid artificial muscle.Therefore,the current development of cell-actuated artificial muscle provides great potential for energy delivery systems as actuators for implantable medibot movement and drug delivery systems.Moreover,the innervation of the biohybrid artificial muscle with motor neurons is of great interest for human-machine interfaces.
基金
This work was supported by the Creative Research Initiative Center for Self-powered Actuation in the National Research Foundation of Korea.
