摘要
目的建立芪黄通秘软胶囊吸湿模型。方法绘制芪黄通秘软胶囊吸湿过程动力学曲线和吸湿等温线,运用OriginPro 2019b统计分析软件进行拟合,以均方根误差(RMSE)和决定系数(R^(2))为评价指标,筛选最佳拟合模型。结果芪黄通秘软胶囊的吸湿动力学曲线和吸湿等温线最优模型分别为双指数模型和Peleg模型,其吸湿等温线属于Ⅱ型等温线。结论所建立的双指数模型和Peleg模型R^(2)较大,RMSE较小,曲线拟合度高,为深入研究软胶囊的吸湿行为和探索高效的防潮策略提供理论指导。
Objective To establish the hygroscopic model of Qihuang Tongmi soft capsules.Methods The dynamic curve and isotherm of the hygroscopic process of Qihuang Tongmi soft capsules were drawn,and the OriginPro 2019b statistical analysis software was used for the fitting.The root mean square error(RMSE)and the coefficient of determination(R^(2))were used as the evaluation indexes to screen the best fitting model.Results The optimal fitting models for hygroscopic dynamic curve and hygroscopic isotherm of Qihuang Tongmi soft capsules were double exponential model and Peleg model,respectively.The hygroscopic isotherm was typeⅡisotherm.Conclusion The established double exponential model and Peleg model have a high degree of curve fitting with large R^(2) and small RMSE.The results provide theoretical guidance for further study of the hygroscopic behavior of soft capsules and exploration of efficient moisture-proof strategies.
作者
乔子桐
付慧敏
张纯刚
郭勇
程岚
QIAO Zi-tong;FU Hui-min;ZHANG Chun-gang;GUO Yong;CHENG Lan(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian Liaoning 116620;Shineway Pharmaceutical Group Co.,Ltd,Shijiazhuang 051430)
出处
《中南药学》
CAS
2022年第1期70-74,共5页
Central South Pharmacy
基金
国家重点研发计划(No.2018YFC1706903)
国家自然科学基金资助项目(No.81503257)
辽宁省博士启动基金(No.201501098)
辽宁省自然科学基金指导计划项目(No.2019-ZD-0968)
中医脏象理论及应用国家教育部重点实验室一般项目(No.zyzx1809)
沈阳市中青年科技创新人才项目(No.RC200204)。
