摘要
目的:观察麝香通心滴丸联合西药治疗稳定型心绞痛(SAP)的临床疗效。方法:选取98例SAP患者,按不同治疗方法分为对照组和观察组,每组49例。对照组给予西药治疗,观察组采用麝香通心滴丸联合西药治疗,2组均连续治疗4周。比较2组治疗前后中医症状评分,心绞痛发作次数,心绞痛持续时间,白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)、血脂指标水平及6 min步行试验(6MWT)距离;比较2组临床疗效。结果:治疗后,2组胸痛、气短、心悸评分均较治疗前降低(P<0.05),观察组胸痛、气短、心悸评分均低于对照组(P<0.05)。治疗后,2组心绞痛发作次数均较治疗前减少(P<0.05),心绞痛持续时间均较治疗前缩短(P<0.05);观察组心绞痛发作次数少于对照组(P<0.05),心绞痛持续时间短于对照组(P<0.05)。治疗后,2组IL-6、hs-CRP、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前降低(P<0.05),观察组IL-6、hs-CRP、TC、TG、LDL-C水平均低于对照组(P<0.05);2组高密度脂蛋白胆固醇(HDL-C)水平均较治疗前升高(P<0.05),观察组HDL-C水平高于对照组(P<0.05);2组6MWT距离均较治疗前增大(P<0.05),观察组6MWT距离大于对照组(P<0.05)。观察组总有效率为93.88%,高于对照组的79.59%(P<0.05)。结论:麝香通心滴丸联合西药治疗SAP可提高临床疗效,有效缓解心绞痛症状,降低炎症因子及血脂水平,增加步行距离。
Objective:To observe the clinical effect of Shexiang Tongxin dropping pills combined with western medicine for stable angina pectoris(SAP).Methods:A total of 98 cases of SAP patients were divided into the control group and the observation group according to different treatment methods,with 49 cases in each group.The control group was treated with western medicine,and the observation group was treated with Shexiang Tongxin dropping pills combined with western medicine.Both groups were treated for four weeks.Chinese medicine syndrome scores,onset frequency and duration of angina pectoris,levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and blood lipid,and distances in Six-Minute Walk Test(6MWT)before and after treatment as well as the clinical effects in the two groups were compared.Results:After treatment,the scores of chest pain,shortness of breath and palpitation in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of chest pain,shortness of breath and palpitation in the observation group were lower than those in the control group(P<0.05).After treatment,the onset frequency of angina pectoris in the two groups was decreased when compared with that before treatment(P<0.05),and the duration of angina pectoris was shortened(P<0.05);the onset frequency of angina pectoris in the observation group was less than that in the control group(P<0.05),and the duration of angina pectoris was shorter(P<0.05).After treatment,the levels of IL-6,hs-CRP,total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-6,hs-CRP,TC,TG and LDL-C in the observation group were lower than those in the control group(P<0.05);the levels of high-density lipoprotein cholesterol(HDL-C)in the two groups were increased when compared with those before treatment(P<0.05),and the HDL-C level in the observation group was higher t
出处
《新中医》
CAS
2021年第24期65-69,共5页
New Chinese Medicine
关键词
稳定型心绞痛
麝香通心滴丸
炎症因子
血脂
6
min步行试验
Stable angina pectoris
Shexiang Tongxin dropping pills
Inflammatory factors
Blood lipid
Six-Minute Walk Test
