摘要
目的探讨妊娠期糖尿病(GDM)孕妇孕中期血清脂联素(APN)水平变化及其临床意义。方法选取2017年1月至2020年10月在该院建档孕检的孕中期孕妇84例为研究对象。将口服葡萄糖耐量试验(OGTT)阳性的37例GDM孕妇纳入GDM组,将OGTT阴性的47例健康孕妇纳入对照组。比较两组APN、空腹血糖(FPG)、脂代谢相关指标水平;分析APN水平与FPG、脂代谢相关指标水平的相关性;分析GDM发生的危险因素。结果 GDM组APN水平低于对照组,FPG和三酰甘油(TG)水平高于对照组,差异有统计学意义(P<0.05)。在GDM组中,APN水平与FPG及TG水平呈负相关(r=-0.94、-0.90,P<0.05)。FPG水平升高、APN水平降低是孕中期孕妇发生GDM的危险因素(P<0.05)。结论孕中期GDM孕妇APN水平明显降低,且APN水平与FPG、TG水平具有一定相关性,APN降低是孕妇发生GDM的危险因素之一。
Objective To explore the changes of serum adiponectin level in the second trimester of pregnant women with gestational diabetes mellitus(GDM) and its clinical significance.Methods A total of 84 pregnant women in the second trimester who had filed pregnancy examinations in the hospital from January 2017 to October 2020 were selected as the research objects.A total of 37 GDM pregnant women with positive oral glucose tolerance test(OGTT) were included in the GDM group, and 47 healthy pregnant women with negative OGTT were included in the control group.Compared the levels of APN,fasting blood glucose(FPG) and lipid metabolism related indicators between the two groups.Analyzed the correlation between APN level and FPG,lipid metabolism related indicators levels.Analyzed the risk factors of GDM.Results The level of APN in the GDM group was lower than that in the control group, and the levels of FPG and triacylglycerol(TG) were higher than those in the control group, the differences were statistically significant(P<0.05).In the GDM group, APN levels were negatively correlated with FPG and TG levels(r=-0.94,-0.90,P<0.05).Increased FPG level and decreased APN level were risk factors for GDM in pregnant women in the second trimester(P<0.05).Conclusion The APN level of pregnant women with GDM in the second trimester reduces significantly, and the APN level has a certain correlation with the FPG and TG levels, decreased APN level is one of the risk factors for GDM in pregnant women.
作者
杜雪丽
王培
DU Xueli;WANG Pei(Department of Obstetrics and Gynecology,Hongqiao Hospital of Wuxi,Wuxi,Jiangsu 214000,China)
出处
《检验医学与临床》
CAS
2022年第2期157-159,共3页
Laboratory Medicine and Clinic
基金
江苏省妇幼保健协会科研项目(FYX201812)
江苏省无锡市卫生和计划生育委员会妇幼健康科研项目(FYKY201805)。
关键词
妊娠期糖尿病
脂联素
孕中期
空腹血糖
gestational diabetes mellitus
adiponectin
second trimester
fasting blood glucose
