摘要
目的 探讨法舒地尔与尼莫地平联合用于治疗脑动脉瘤血管内介入栓塞术后血管痉挛(CVS)的效果。方法选择我院2018年10月—2021年2月收治的94例脑动脉瘤血管介入栓塞术后CVS患者,以随机数字表法将其分为研究组与对照组,各47例,对照组:尼莫地平治疗,研究组:法舒地尔+尼莫地平治疗。对比疗效、大脑中动脉(MCA)及大脑后动脉(PCA)平均血流速度、格拉斯哥(COS)评分、美国国立卫生研究院卒中量表(NIHSS)评分以及不良反应发生率。结果 研究组治疗有效率高(P <0.05);治疗前,组间MCA、PCA平均血流速度对比差异无统计学意义(P>0.05),治疗后,研究组MCA、PCA平均血流速度低(P <0.05);治疗前,组间COS、NFI评分对比差异无统计学意义(P>0.05),治疗后,研究组COS评分高,NIHSS评分低(P <0.05);组间不良反应发生率对比差异无统计学意义(P>0.05)。结论 联合应用法舒地尔、尼莫地平可缓解脑动脉瘤栓塞术后CVS患者脑血管痉挛现象,改善MCA、PCA血流速度。
Objective To investigate the effect of fasudil combined with nimodipine in the treatment of cerebral aneurysm vasospasm(CVS)after endovascular embolization for treating cerebral aneurysm.Methods This study selected a total of 94 CVS patients who were admitted to our hospital from October 2018 to February 2021 after endovascular embolization for treating cerebral aneurysm.They were divided into the study group and the control group by random number table method,with 47 patients in each group.The control group was treated with nimodipine alone.The study group was treated with fasudil+nimodipine.The researchers compared the efficacy,the mean blood flow velocity of middle cerebral artery(MCA)and posterior cerebral artery(PCA),Glasgow(COS)score,National Institutes of Health Stroke Scale(NIHSS)score and incidence of adverse reactions.Results The effective rate of the study group was higher(P<0.05).Before treatment,there was no difference in the mean blood flow velocity of MCA and PCA between two groups(P>0.05).After treatment,the mean blood flow velocity of MCA and PCA in the study group was low(P<0.05).Before treatment,there was no difference in COS and NFI scores between two groups(P>0.05).After treatment,the COS score of the study group was higher and their NIHSS score was lower(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Fasudil combined with nimodipine can relieve CVS and improve the blood flow velocity of MCA and PCA in patients with CVS after endovascular embolization for treating cerebral aneurysm.
作者
臧广霞
李军朋
黄圣明
李燕
Zang Guangxia;Li Junpeng;Huang Shengming;Li Yan(Department of Neurology,People’s Hospital of Linying County,Linying 462600,Henan,China;Department of Neurology,Luohe Central Hospital,Luohe 462000,Henan,China;Department of Neurology,People’s Hospital of Zhengzhou University,Zhengzhou 450003,Henan,China)
出处
《右江民族医学院学报》
2021年第6期757-759,773,共4页
Journal of Youjiang Medical University for Nationalities
基金
河南省医学科技攻关计划项目(LHGJ202001122)。
