摘要
目的探讨纳豆提取物对骨质疏松症的预防作用,为进一步研究纳豆提取物对骨质疏松的预防和治疗提供理论依据。方法通过大鼠实验研究纳豆提取物对低钙饲料喂养大鼠体重、身长、钙吸收率、股骨质量、骨密度和骨钙含量的影响。结果(1)高剂量组(P<0.05)、碳酸钙组(P<0.05)的体重显著大于低钙对照组。高剂量组(P<0.05)的钙吸收率显著大于碳酸钙对照组。(2)各剂量组(P<0.05)、碳酸钙组(P<0.05)的股骨干重均显著大于低钙对照组。(3)高剂量组的股骨骨密度(P<0.05)和骨钙含量(P<0.05)均显著大于低钙对照组,且不低于碳酸钙对照组。结论经口灌胃给予大鼠不同剂量的纳豆提取物90 d,实验组大鼠的股骨骨密度、骨钙含量显著高于低钙对照组且不低于碳酸钙对照组,钙吸收率不低于碳酸钙对照组,结果表明纳豆可以通过促进钙吸收增加骨量,提示其在预防骨质疏松症中可能发挥作用。
Objective To investigate the preventive effect of natto extract on osteoporosis,and to provide a theoretical basis for further research on the prevention and treatment of osteoporosis.Methods By using the rat experimental study,the effects of natto extract on the body weight,body length,calcium absorption rate,and bone mineral density and bone calcium content of the femur of low-calcium-feeding rats were studied.Results(1)The body weight in rats of high dose group and calcium carbonate group was significantly greater than that in low calcium control group.The calcium absorption rate in high dose group was significantly higher than that in calcium carbonate control group(P<0.05).(2)The dry-weight of the femur in each dose group and calcium carbonate group was significantly higher than that in low calcium control group(P<0.05).(3)Bone mineral density and bone calcium content of the femur in high dose group were significantly greater than those in low calcium control group,and were not lower than those in calcium carbonate control group.Conclusion After giving different doses of the extract in rats by mouth for 90 days,bone mineral density and bone calcium content of the femur in rats were significantly higher than those in low calcium control group and not less than calcium carbonate group,and the rate of calcium absorption was not less than calcium carbonate group.The result show that natto increases bone mass by promoting calcium absorption,suggesting its possible role in preventing osteoporosis.
作者
蔡铁全
李莹
徐建文
曹璨
刘影
CAI Tiequan;LI Ying;XU Jianwen;CAO Can;LIU Ying(Center for Food Evaluation,State Administration for Market Regulation,Beijing 100070;Harbin Medical University,Harbin 150001,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2022年第1期26-30,共5页
Chinese Journal of Osteoporosis
关键词
纳豆提取物
骨质疏松症
骨密度
natto extract
osteoporosis
bone mineral density
