摘要
目的应用瞬时弹性成像测量肝脏硬度值(LSM)评价门静脉海绵样变性(CTPV)患者肝硬化情况。方法回顾2012年1月至2021年4月新乡市中心医院收治的CTPV患者22例(男12例、女10例),年龄(50.2±11.8)岁。同时选取同期慢性乙型肝炎相关肝硬化患者30例作为对照组。计量资料采用t检验或Mann-Whitney U检验,计数资料采用χ2检验。结果两组临床资料比较,CTPV组ALT、AST及ALP分别为36(22,52)、38(26,56)及71(52,92)U/L,与对照组[19(14,31)、26(19,42)及88(72,116)U/L]相比,差异具有统计学意义(P<0.05);CTPV组、对照组LSM分别为12.6(6.8,21.4)、21.2(15.4,26.8)kPa,差异具有统计学意义(P<0.05);CTPV组肝纤维化分期F0-1期、F2-3期及F4期分别为8例(36.4%)、2例(9.1%)及12例(54.5%),对照组F0-1期、F2-3期及F4期分别为0(0)、0(0)及30(100),差异具有统计学意义(P<0.05)。比较CTPV患者伴有肝硬化(肝硬化组)、不伴有肝硬化(无肝硬化组)资料,肝硬化组、非肝硬化组年龄分别为(56.2±13.8)、(44.1±9.7)岁,差异具有统计学意义(P<0.05);肝硬化组、非肝硬化组ALb分别为35.0(35.0,40.2)、39.6(38.2,42.7)g/L,差异具有统计学意义(P<0.05);肝硬化组、非肝硬化组HBsAg阳性为9例(75.0%)、2例(20.0%),差异具有统计学意义(P<0.05);肝硬化组、非肝硬化组HVPG分别为16.8(13.2,22.0)、6.4(5.0,9.8)mmHg,差异具有统计学意义(P<0.05);肝硬化组、非肝硬化组LSM分别为17.6(6.8,29.5)、6.8(5.3,8.2)kPa,差异具有统计学意义(P<0.05)。结论CTPV患者LSM值与慢性乙型肝炎相关肝硬化存在显著差异,同时CTPV肝硬化LSM值明显高于无肝硬化患者,瞬时弹性成像测量LSM可有效评价CTPV患者肝硬化情况。
Objective To evaLuate Liver cirrhosis in patients with cavernous transformation of portaL vein(CTPV)by measurement of Liver stiffness measurement(LSM)using transient eLastography.Methods From January 2012 to ApriL 2021,22 CTPV patients(12 maLes and 10 femaLes)with an age of(50.2±11.8)years were reviewed.MeanwhiLe,30 patients with chronic hepatitis B reLated cirrhosis were selected as control group.t-test or Mann-Whitney U-test was used for measurement data,and Chi-square test was used for counting data.Results Comparing the cLinicaL data of CTPV patients(CTPV group)and controL group,ALT,AST and ALP in CTPV group were 36(22,52),38(26,56)and 71(52,92)U/L,which were significantly higher than those in control group[19(14,31),26(19,42)and 88(72,116)U/L,P<0.05].The LSM of CTPV group and control group were 12.6(6.8,21.4)and 21.2(15.4,26.8)kPa,the difference was statistically significant(P<0.05).The staging of liver fibrosis in CTPV group was 8(36.4%),2(9.1%)and 12 cases(54.5%),while that in control group was 0(0),0(0)and 30(100),the difference was statistically significant(P<0.05).Comparing the data of CTPV patients with cirrhosis(cirrhosis group)and without cirrhosis(non-cirrhosis group),the ages of cirrhosis group and non-cirrhosis group were(56.2±13.8)and(44.1±9.7)years,and the difference was statistically significant(P<0.05).The Alb of cirrhosis group and non-cirrhosis group were 35.0(35.0,40.2)and 39.6(38.2,42.7)g/L,with statistical significance(P<0.05).The HBsAg in cirrhosis group and non-cirrhosis group was 9(75.0%)and 2(20.0%),with statistical significance(P<0.05).HVPG in cirrhotic group and non-cirrhotic group was 16.8(13.2,22.0)and 6.4(5.0,9.8)mmHg,the difference was statistically significant(P<0.05).The LSM of cirrhosis group and non-cirrhosis group were 17.6(6.8,29.5)and 6.8(5.3,8.2)kPa,with statistical significance(P<0.05).Conclusion The LSM value of CTPV patients is significantly different from that of chronic hepatitis B-related cirrhosis,and the LSM value of CTPV patients with cirrhosis is significant
作者
石太英
韩华
李建玲
SHI Tai-ying;HAN Hua;LI Jian-Ling(Department of ULtrasound,Xinxiang CentraL HospitaL,Henan 453000,China)
出处
《肝脏》
2021年第12期1401-1403,共3页
Chinese Hepatology
关键词
门静脉海绵样变性
肝脏硬度值
肝硬化
Cavernous transformation of portal vein
Liver stiffness measurement
Liver cirrhosis
