摘要
目的探讨飞行人员肺癌的临床特征及其对复发转移的影响。方法回顾性分析2004年1月—2020年12月空军特色医学中心诊治的12例飞行人员肺癌患者的临床及病理特征,并进行Cox比例风险模型分析,并对全部特征因素进行单因素和多因素分析。结果入组的12例病例中,发病年龄37~67岁,中位年龄48.5岁,中位飞行时间3050 h。12例肺癌患者截止2020年12月复发转移6例(50.0%),死亡4例(33.3%)。经单因素分析,临床症状、肿瘤标记物异常和淋巴结转移与飞行人员肺癌病情进展有关,多因素分析显示,临床症状是影响飞行人员肺癌无进展生存时间的独立风险因素。在相关性分析中,发现肿瘤时的临床症状与淋巴结转移、TNM分期和肺癌复发转移之间存在相关性,肿瘤标记物异常与淋巴结转移、TNM分期、肺癌复发转移有关,飞行时间与淋巴结转移呈正相关。结论临床症状是影响飞行人员肺癌复发转移的风险因素。对存在高风险和与肺癌相关的临床特征的飞行人员进行积极检查和治疗,可延长无进展生存时间,进而可有效延长飞行人员的飞行寿命。
Objective To investigate the clinical character istics of lung cancer in aircrew and their influence on recurrence and metastasis.Methods The clinical and pathological data on 12 patients with lung cancer treated in Air Force Special Medical Center between January 2004 and December 2020 was retrospectively analyzed.A Cox proportional risk model was used to analyze all the related factors,and univariate and multivar iate analyses were conducted.Results A mong the 12 cases,the onset age ranged from 37 to 67 years old,the median age was 48.5 years old,and the median flight time was 3050 hours.Six of these cases(50.0%)had recurrence or metastasis and 4 cases(33.3%)died by December 2020.Univar iate analysis showed that clinical symptoms,abnormal tumor markers and lymph node metastasis were associated with lung cancer progression in aircrew.Multivariate analysis showed that clinical symptoms were independent risk factors affecting the progression-free survival time of lung cancer in aircrew.Correlation analysis revealed that the clinical symptoms of tumor were correlated with lymph node metastasis,TNM stage,and recurrence and metastasis of lung cancer,so were abnormal tumor markers.Flight time was positively correlated with lymph node metastasis.Conclusion Clinical symptoms are risk factors for recurrence and metastasis of lung cancer in flight personnel.Active examination and treatment of flight personnel at high risk and with clinical features related to lung cancer can prolong their prog ression-free survival and careers.
作者
毛志远
王宇
刘菊琴
姚毅冰
于海燕
夏秀玲
晋颖
孙璐璐
樊再雯
MAO Zhiyuan;WANG Yu;LIU Juqin;YAO Yibing;YU Haiyan;XIA Xiuling;JIN Ying;SUN Lulu;FAN Zaiwen(Department of Oncology,Air Force Medical Center of PLA,Beijing 100142,China)
出处
《空军医学杂志》
2021年第5期383-385,428,共4页
Medical Journal of Air Force
基金
北京市科学技术委员会资助项目(Z171100000417029)。
关键词
飞行人员
肺恶性肿瘤
肿瘤复发转移
多因素分析
临床特征
aircrew
lung malignancy
tumor recurrence and metastasis
multivariate analysis
clinical features
