摘要
目的:观察用盐酸西那卡塞联合碳酸司维拉姆治疗慢性肾衰竭后继发性甲状旁腺功能亢进及高磷血症的效果。方法:选取2020年6月至2021年6月在佛山市高明区人民医院接受治疗的慢性肾衰竭后继发性甲状旁腺功能亢进及高磷血症患者70例,将其随机分为常规组和西那-司维组,每组35例患者。为常规组患者采用骨化三醇联合碳酸钙进行治疗,为西那-司维组患者采用盐酸西那卡塞联合碳酸司维拉姆进行治疗。然后对比两组患者的临床疗效。结果:西那-司维组患者治疗的总有效率高于常规组患者,P<0.05。治疗前,两组患者血清全段甲状旁腺激素(iPTH)、甲状旁腺激素(PTH)、血磷、血钙的水平相比,P>0.05。治疗后,西那-司维组患者血清iPTH、PTH、血磷、血钙的水平均低于常规组患者,P<0.05。结论:用盐酸西那卡塞联合碳酸司维拉姆治疗慢性肾衰竭后继发性甲状旁腺功能亢进及高磷血症的效果较为理想。
Objective:To observe the efficacy of sinacasel hydrochloride combined with selveram carbonate in the treatment of secondary hyperparathyroidism and hyperphosphoemia after chronic renal failure.Methods:Seventy patients with chronic renal failure followed by hyperparathyroidism and hyperphosphoemia who were treated in Foshan Gaoming District People’s Hospital from June 2020 to June 2021 were selected and randomly divided into conventional group and Sina-Siv group,with 35 patients in each group.Patients in the conventional group were treated with calcitriol combined with calcium carbonate,and patients in the sina-Sivir group were treated with sinacase hydrochloride combined with selveram carbonate.Then the clinical efficacy of the two groups was compared.Results:The total effective rate of sina-siv group was higher than that of conventional group,P<0.05.Before treatment,the serum levels of whole parathyroid hormone(iPTH),parathyroid hormone(PTH),blood phosphorus and blood calcium in 2 groups were compared,P>0.05.After treatment,the levels of serum iPTH,PTH,blood phosphorus and blood calcium in sina-Siv group were lower than those in conventional group,P<0.05.Conclusion:The efficacy of sinacasel hydrochloride combined with selveram carbonate in the treatment of secondary hyperparathyroidism and hyperphosphoemia after chronic renal failure is ideal.
作者
郑木玲
范国锋
郭婷婷
魏晶
ZHENG MuLing;FAN Guofeng;GUO Tingting;WEI Jing(Department of Nephrology,Gaoming District People’s Hospital,Foshan 528500)
