摘要
Epilepsy is a common disease in the central nervous system.There is growing evidence that epilepsy is associated with glial cells,including astrocytes.Tumor necrosis factorα(TNFα)is a“master regulator”of proinflammatory cytokine production and is secreted by microglia and astrocytes.TNFαsecreted by microglia can activate astrocytes.Additionally,TNFαcan regulate neuron activity and induce epilepsy by increasing the glutamate release,reducing the expression ofγ-aminobutyric acid,inducing neuroinflammation and affecting the synaptic function in astrocytes.This review summarizes the signaling pathways and receptors of TNFαacting on astrocytes that are related to epilepsy and provides insights into the potential therapeutic strategies of epilepsy for clinical practice.
基金
supported by the UCB Foundation of China Association Against Epilepsy(2017007)
the National Natural Science Foundation of China(81601038)
the Department of Resource and Social Security of Shanxi Province(Jin fiscal and Social Council[2019]91st).
