摘要
目的探究血府逐瘀颗粒联合穴位贴敷治疗原发性痛经对血液流变学及β-内啡肽(β-EP)、前列腺素E2 (PGE2)含量的影响。方法回顾性分析2017年6月至2020年6月在榆林市榆阳区妇幼保健院接受治疗的原发性痛经患者的临床资料,选取穴位敷贴治疗的50例原发性痛经患者作为对照组,血府逐瘀颗粒联合穴位敷贴治疗的50例原发性痛经患者作为观察组。比较两组患者的临床疗效,治疗前后的全血还原黏度(WBRV)、血浆黏度(PV)、纤维蛋白原(FIB)、红细胞压积(HCT)、β-EP、PGE2水平及腹痛视觉模拟评分法(VAS)评分。结果观察组患者的治疗总有效率为94.0%,明显高于对照组的76.0%,差异有统计学意义(P<0.05);两组治疗后WBRV、PV、FIB、HCT水平均低于治疗前,且治疗后,观察组患者的WBRV、PV、FIB、HCT分别为(2.68±0.44) mPa·s、(1.20±0.21) mPa·s、(2.63±0.25) g/L、(40.55±4.47)%,明显低于对照组的(4.24±0.53) mPa·s、(1.62±0.26) mPa·s、(4.41±0.36) g/L、(44.63±4.12)%,差异均有统计学意义(P<0.05);两组治疗后β-EP、PGE2水平升高,VAS评分降低,且治疗后,观察组患者的β-EP、PGE2水平及VAS评分分别为(192.89±23.86) ng/L、(290.25±33.27) ng/L、(2.30±0.46)分,明显低于对照组的(164.27±19.84) ng/L、(251.44±34.64) ng/L、(4.50±0.71)分,差异均有统计学意义(P<0.05)。结论血府逐瘀颗粒联合穴位贴敷治疗原发性痛经疗效显著,且能显著改善患者的血液流变学指标,促进局部血液循环,其机制可能与调节β-EP、PGE2水平有关。
Objective To explore the effects of Xuefu Zhuyu Granules combined with acupoint application in the treatment of primary dysmenorrhea on blood rheology and the content of β-endorphin(β-EP) and prostaglandin E2(PGE2). Methods The clinical medical records of patients with primary dysmenorrhea who were treated at the Maternal and Child Health Hospital of Yuyang District of Yulin City from June 2017 to June 2020 were retrospectively analyzed. Fifty patients with primary dysmenorrhea treated by acupoint application were selected as the control group, and50 patients with primary dysmenorrhea treated by Xuefu Zhuyu Granules combined with acupoint application were used as the observation group. The clinical efficacy, whole blood reduced viscosity(WBRV), plasma viscosity(PV), fibrinogen(FIB), hematocrit(HCT), β-EP, PGE2 level, and Visual Analogue Scale(VAS) score for abdominal pain were compared between the two groups before and after treatment. Results The total effective rate of treatment in the observation group was 94.0%, which was significantly higher than 76.0% in the control group(P<0.05). The levels of WBRV,PV, FIB, and HCT in the two groups after treatment were lower than those before treatment. After treatment, the WBRV,PV, FIB, and HCT of the observation group were(2.68 ± 0.44) mPa·s,(1.20 ± 0.21) mPa·s,(2.63 ± 0.25) g/L,(40.55 ±4.47)%, which are significantly lower than(4.24±0.53) mPa·s,(1.62±0.26) mPa·s,(4.41±0.36) g/L,(44.63±4.12)% in the control group(P<0.05). The levels of β-EP and PGE2 increased and VAS score decreased in the two groups after treatment;the β-EP, PGE2 levels, and VAS scores of the observation group were(192.89 ± 23.86) ng/L,(290.25 ±33.27) ng/L,(2.30±0.46) points, which were significantly lower than(164.27±19.84) ng/L,(251.44±34.64) ng/L,(4.50±0.71) points in the control group(P<0.05). Conclusion Xuefu Zhuyu Granules combined with acupoint application has significant curative effect on primary dysmenorrhea, which can significantly improve the patient’s blood rheolog
作者
吴会珍
陈琳
于全瑞
樊延霞
WU Hui-zhen;CHEN Lin;YU Quan-rui;FAN Yan-xia(Department of Reproduction,the Maternal and Child Health Hospital of Yuyang District of Yulin City,Yulin 719000,Shaanxi,CHINA;Department of Obstetrics,the Fourth People's Hospital of Yan'an City,Yan'an 716000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2022年第1期13-16,共4页
Hainan Medical Journal
