摘要
目的探讨粒细胞/淋巴细胞(NLR)、高迁移率族蛋白1(HMGB1)、降钙素原(PCT)在预测新生儿败血症预后的临床价值。方法收集承德市妇幼保健院2016年9月至2021年3月收治的281例新生儿败血症一般临床资料(败血症组),另选取103例同期住院的非败血症的一般感染患儿纳入对照组,比较两组NLR、HMGB1、PCT水平。依据预后情况将败血症患儿纳入预后良好组与预后不良组,并探讨NLR、HMGB1、PCT在新生儿败血症预后中的预测效能。结果败血症组NLR、HMGB1、PCT水平均显著高于对照组,差异均有统计学意义(P<0.05)。281例新生儿败血症中有245例预后良好(预后良好组)、36例预后不良(预后不良组)。NLR、HMGB1、PCT是影响新生儿败血症预后的独立危险因素(P<0.05)。联合NLR、HMGB1、PCT预测新生儿败血症患儿不良预后AUC为0.921,显著高于单一指标预测效能(P<0.05)。结论 NLR、HMGB1、PCT是影响新生儿败血症预后的独立危险因素,联合以上指标对预测新生儿败血症不良预后有重要价值。
Objective To investigate the clinical prognostic value of neutrophil-to-lymphocyte ratio(NLR),high mobility group box 1(HMGB1)and procalcitonin(PCT)in neonatal sepsis. Methods The general clinical data of 281 cases of neonatal sepsis(sepsis group)admitted to Chengde Maternal and Child Health Care Hospital were collected from September 2016 to March 2021. Meanwhile,103 neonates with common infection but not sepsis were selected as the control group. The levels of NLR,HMGB1 and PCT were compared between the two groups. According to the prognosis,the children with sepsis were divided into the good prognosis group(n=245)and the poor prognosis group(n=36). The prognostic efficiencies of NLR,HMGB1 and PCT for neonatal sepsis was discussed. Results The levels of NLR,HMGB1 and PCT in the sepsis group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05). NLR,HMGB1,and PCT were independent risk factors affecting the prognosis of neonatal sepsis(P<0.05). The AUC of joint prediction with NLR,HMGB1 and PCT was 0.921,which was significantly higher than that of single indicator prediction(P<0.05). Conclusion NLR,HMGB1 and PCT are independent risk factors affecting the prognosis of neonatal sepsis,and the combination of the above indicators has important value in predicting the poor prognosis of neonatal sepsis.
作者
杨春光
刘海红
王凤东
刘军
YANG Chunguang;LIU Haihong;WANG Fengdong;LIU Jun(Chengde Maternal and Child Health Care Hospital,Chengde,Hebei,China,067000)
出处
《分子诊断与治疗杂志》
2021年第12期2017-2020,2025,共5页
Journal of Molecular Diagnostics and Therapy
基金
承德市科学技术研究与发展计划课题(202006A008)。
