摘要
目的探讨氨氯地平联合阿托伐他汀钙片对高血压合并冠心病的治疗效果。方法选取2019年1月至12月抚顺市中医院收治的94例高血压合并冠心病患者作为研究对象,按照随机数字表法分为替米组(47例)和氨氯地平组(47例),替米组采用阿托伐他汀钙片联合替米沙坦治疗,氨氯地平组采用阿托伐他汀钙片联合苯磺酸氨氯地平片治疗。比较两组患者治疗前后的血压、白细胞介素2(IL-2)、一氧化氮(NO)、内皮素(ET)、同型半胱氨酸水平(Hcy)及颈动脉内中膜厚度(IMT)。结果两组治疗前血压比较,差异无统计学意义(P>0.05)。治疗后,两组的收缩压、舒张压均低于治疗前,且氨氯地平组收缩压、舒张压低于替米组,差异有统计学意义(P<0.05)。两组治疗前实验室指标比较,差异无统计学意义(P>0.05)。治疗后,两组的IL-2、Hcy、ET水平低于治疗前,NO水平高于治疗前,且氨氯地平组IL-2、Hcy、ET水平低于替米组,NO水平高于替米组,差异有统计学意义(P<0.05)。两组治疗前IMT比较,差异无统计学意义(P>0.05)。治疗后,两组IMT低于治疗前,且氨氯地平组IMT低于替米组,差异有统计学意义(P<0.05)。结论苯磺酸氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病,具有平衡管腔收张功能、促血管损伤修复、缓解血管壁压力、改善血管平滑肌功能、延缓炎症反应发生、抑制小血管痉挛等功效。
Objective To explore the therapeutic effect of Amlodipine combined with Atorvastatin Calcium Tablets on hypertension complicated with coronary heart disease.Methods A total of 94 patients with hypertension complicated with coronary heart disease admitted to Fushun Hospital of Traditional Chinese Medicine from January to December 2019 were selected as the study subjects,and were divided into Telmisartan group(n=47)and Amlodipine group(n=47)according to random number table method.Telmisartan group was treated with Atorvastatin Calcium Tablets combined with Telmisartan,and Amlodipine group was treated with Atorvastatin Calcium Tablets combined with Amlodipine Besylate Tablets.Blood pressure,interleukin-2(IL-2),nitric oxide(NO),endothelin(ET),homocysteine(Hcy)and carotid intimedia thickness(IMT)were compared between two groups before and after treatment.Results There was no significant difference in blood pressure between the two groups before treatment(P>0.05).After treatment,systolic blood pressure and diastolic blood pressure in both groups were lower than before,and systolic blood pressure and diastolic blood pressure in Amlodipine group were lower than those in Telmisartan group,the differences were statistically significant(P<0.05).There was no significant difference in laboratory indexes between the two groups before treatment(P>0.05).After treatment,the levels of IL-2,Hcy and ET in the two groups were lower than before treatment,and the level of NO was higher than before treatment.The levels of IL-2,Hcy and ET in the Amlodipine group were lower than that in the Telmisartan group,and the level of NO was higher than that in the temib group,the differences were statistically significant(P<0.05).There was no significant difference in IMT between the two groups before treatment(P>0.05).After treatment,IMT in the two groups was lower than before,and IMT in the Amlodipine group was lower than that in the Telmisartan group,the difference was statistically significant(P<0.05).Conclusion Amlodipine Besylate combined wi
作者
白森
BAI Sen(Department of Cardiology,Fushun Hospital of Traditional Chinese Medicine,Liaoning Province,Fushun113000,China)
出处
《中国当代医药》
CAS
2022年第1期72-75,共4页
China Modern Medicine
关键词
氨氯地平
阿托伐他汀钙片
冠心病
高血压
联合用药
Amlodipine
Atorvastatin Calcium Tablets
Coronary heart disease
Hypertension
Drug combination
