摘要
目的:观察血必净注射液联合加贝酯对重症急性胰腺炎(SAP)患者血流动力学及肠黏膜屏障功能的影响。方法:选取2018年3月~2019年10月本院收治的86例SAP患者,按照随机数字表法分为对照组和观察组,每组43例。在常规治疗基础上,对照组给予加贝酯治疗,观察组给予加贝酯+血必净注射液,均治疗10天。治疗前、治疗10天时,评估两组急性生理学及慢性健康状况评分(APACHEⅡ);评估两组各时点血流动力学相关指标[心率(HR)、平均动脉压(MAP)、中心静脉压(CVP)];评估两组各时点肠黏膜屏障功能相关指标[D-乳酸、二胺氧化酶(DAO)、尿乳果糖/甘露醇(L/M)];记录两组治疗期间不良反应发生情况。结果:治疗10天时,两组APACHEⅡ评分、HR、D-乳酸和DAO水平、L/M比值较治疗前降低,MAP和CVP水平较治疗前升高,且观察组APACHEⅡ评分、HR、D-乳酸和DAO水平、L/M比值均低于对照组,MAP和CVP水平均高于对照组,具有统计学差异(P<0.05);两组不良反应发生率比较无统计学差异(P>0.05)。结论:血必净注射液联合加贝酯治疗SAP可有效促进患者血流动力学恢复,改善肠黏膜屏障功能,且安全性良好。
Objective:To observe the effect of Xuebijing injection combined with gabexate on hemodynamics and intestinal mucosal barrier function in patients with severe acute pancreatitis(SAP).Methods:A total of 86 SAP patients treated in the hospital from March 2018 to October 2019 were selected,they were divided by the random number table method into a control group and an observation group,43 cases in each group.The control group was received conventional treatment+gabexate treatment;on this basis,the observation group was added with Xuebijing injection,both groups were treated for 10 days.Before treatment and at 10 days of treatment,acute physiology and chronic health score(APACHEⅡ)were evaluated between the two groups;at each time point,the hemodynamic related indexes[heart rate(HR),mean arterial pressure(MAP),central venous pressure(CVP)]were evaluated between the two groups;at each time point,the related indexes of intestinal mucosal barrier function[D-lactic acid,diamine oxidase(DAO),urine lactulose/mannitol(L/M)]were evaluated between the two groups;the adverse reactions of the two groups during treatment were recorded.Results:At 10 days of treatment,the APACHEⅡscore,HR,levels of D-lactic acid and DAO,L/M ratio of both groups were decreased than those before treatment,while the MAP and CVP levels were increased than those before treatment,and the APACHEⅡscore,HR,levels of D-lactic acid and DAO,L/M ratio of the observation group were lower than those of the control group,while the levels of MAP and CVP were higher the control group,with statistical significant differences(P<0.05);there was no statistical significant difference in that those of the incidence of adverse reactions of both groups(P>0.05).Conclusion:Xuebijing injection combined with gabexate in the treatment of SAP can effectively promote the recovery of hemodynamics of patients,and can improve the intestinal mucosal barrier function,with high safety.
作者
丁勇
龙四军
李静
DING Yong;LONG Si-jun;LI Jing(Department of Critical Care Medicine,General Hospital of Yima Coal Industry Group Co.,Yima 472300,China)
出处
《中国合理用药探索》
2021年第12期104-108,共5页
Chinese Journal of Rational Drug Use
关键词
重症急性胰腺炎
加贝酯
血必净注射液
血流动力学
肠黏膜屏障功能
不良反应
severe acute pancreatitis
gabexate
Xuebijing injection
hemodynamics
intestinal mucosal barrier function
adverse reactions
