摘要
目的探究甲型H1N1流感(简称“甲型流感”)样发热聚集性患者予以五虎合剂联合磷酸奥司他韦治疗的临床效果。方法纳入试验研究的200例甲型流感样发热聚集性患者均为桂林市中医医院收治,入组时间为2020年7月至2021年6月,按随机数字表法分为两组,每组各100例。对照组仅予以常规西药磷酸奥司他韦治疗,研究组基于对照组配合五虎合剂治疗,对比两组总有效率、细胞免疫指标及不良反应发生情况。结果在治疗效果方面,研究组的总有效率为96.00%,高于对照组的79.00%(P<0.05);治疗后研究组的CD4^(+)、IgM及IgA水平高于对照组,且研究组与对照组治疗后的CD4^(+)、IgM及IgA水平高于治疗前,差异有统计学意义(P<0.05);研究组不良反应总发生率为4.00%,低于对照组的16.00%(P<0.05)。结论甲型流感样发热聚集性患者予五虎合剂联合磷酸奥司他韦治疗,可改善患者细胞免疫指标,提高临床疗效,减少不良反应,改善用药预后效果,保证安全治疗,临床实践价值较高。
Objective To explore the clinical effect of Wuhu Mixture combined with oseltamivir phosphate in the treatment of patients with a cluster of influenza A(H1N1)-like fever.Methods A total of 200 patients with a cluster of H1N1-like fever were admitted to Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi from July 2020 to June 2021,and were randomly divided into two groups,with 100 cases in each group.The control group was only treated with oseltamivir phosphate,and the study group was treated with Wuhu Mixture combined with the same medication of the control group.The total effective rate,cellular immune indexes and adverse reactions of the two groups were compared.Results In terms of therapeutic effect,the total effective rate of 96.00%in the study group,which was higher than the 79.00%of the control group(P<0.05).The levels of CD4^(+),IgM and IgA in the study group were higher than those in the control group after treatment,and the CD4^(+),IgM and IgA levels of the study group and the control group after treatment were higher than before treatment,the difference was statistically significant(P<0.05).The total incidence of adverse reactions was 4.00%of the study group,which was lower than the 16.00%of the control group(P<0.05).Conclusion Wuhu Mixture combined with oseltamivir phosphate can improve the cellular immune indexes,increase the clinical efficacy,prevent adverse reactions,improve the prognosis and decrease safe treatment in patients with a cluster of H1N1-like fever.It is of high value in clinical practice.
作者
陈丽娟
蒋文钧
申晋
周欣怡
CHEN Lijuan;JIANG Wenjun;SHEN Jin;ZHOU Xinyi(Emergency Department,Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi,Guilin 541002,China)
出处
《中国医药科学》
2021年第23期13-15,77,共4页
China Medicine And Pharmacy
基金
广西壮族自治区中医药管理局科研课题(GZZC2020306)。
