摘要
目的探讨痰热清注射液对重症胰腺炎合并肺部感染患者血氧水平、降钙素原(Procalcitonin,PCT)及高迁移率族蛋白B1(High Mobility Group Box-1,HMGB1)的影响。方法随机选择2018年1月-2019年1月在我院就诊的重症胰腺炎合并肺部感染患者84例,计算机分为对照组42例、观察组42例。对照组采取常规抗感染、胰腺分泌抑制、维持水和电解质平衡、营养支持,观察组在对照组基础上联用痰热清注射液。观察两组患者肺功能情况、HMGB1和PCT水平、血气指标、疗效指标、不良反应。结果两组治疗前FVC、FEV_(1)值比较无统计学差异(P>0.05),观察组治疗后FVC、FEV_(1)值高于对照组(P<0.05);治疗前PCT、HMGB1水平比较无差异(P>0.05),观察组治疗后PCT、HMGB1水平显著低于对照组;两组治疗前PO_(2)、PCO_(2)、SpO_(2)值比较无差异(P>0.05),观察组治疗后PO_(2)、SpO_(2)值高于对照组,PCO_(2)值低于对照组(P<0.05);两组患者治疗前血清淀粉酶、白细胞计数比较无差异(P>0.05),治疗后观察组血清淀粉酶、白细胞计数低于对照组(P<0.05);对照组不良反应发生率高于观察组,但比较差异无统计学意义(P>0.05)。结论痰热清注射液用于重症胰腺炎合并肺部感染患者的辅助治疗,能有效恢复患者肺功能,降低炎症因子PCT及HMGB1水平,增加抗感染效果,利于病情归转。
Objective To investigate effect of Tanreqing Injection on blood oxygen level,procalcitonin(PCT)and high mobility group box-1(HMGB1)in patients with severe pancreatitis complicated with pulmonary infection.Methods 84 patients with severe pancreatitis and pulmonary infection in our hospital from January 2018 to January 2019 were selected and randomly divided into two groups by computer,each with 42 cases.Control group received the routine anti-infection,inhibition of pancreatic secretion,maintenance of water and electrolyte balance,and nutritional support,based on this,the observation group received the Tanreqing Injection.The pulmonary function,inflammatory factor level,blood gas index,clinical efficacy and adverse reactions were observed in the two groups.Results FVC and FEV_(1) showed no difference between the two groups before treatment(P>0.05),which were lower in the control group than in the observation group after treatment(P<0.05).PCT and HMGB1 levels showed no difference between the two groups before treatment(P>0.05),which were higher in the control group than in the observation group after treatment(P<0.05).PO_(2),PCO_(2) and SpO_(2) values showed no difference between the two groups before treatment(P>0.05).After treatment,the observation group had higher PO_(2) and SpO_(2) values as well as lower PCO_(2) values than those of the control group(P<0.05).Serum amylase and white blood cell count showed no difference between the two groups before treatment(P>0.05),which were lower in the control group than in the observation group after treatment(P<0.05).The incidence of adverse reactions in the control group was higher than that in the observation group,with no statistic difference(P>0.05).Conclusion Tanreqing Injection can effectively restore the pulmonary function,reduce the level of inflammatory factors PCT and HMGB1,increase the anti-infection effect,as well as improve the prognosis of patients with severe pancreatitis complicated with pulmonary infection.
作者
刘博
Liu Bo(Nanyang Central Hospital,Nanyang,Henan 473000)
出处
《辽宁医学杂志》
2021年第6期58-61,共4页
Medical Journal of Liaoning
关键词
痰热清注射液
重症胰腺炎
肺部感染
炎症水平
Tanreqing injection
Severe pancreatitis
Pulmonary infection
Inflammation level
