摘要
目的观察结直肠癌患者血清前梯度同源蛋白2(anterior gradient 2,AGR2)水平与临床病理特征间关系,探讨其对结直肠癌的诊断价值。方法采集45例结直肠癌患者(结直肠癌组)和25例肠道非恶性肿瘤患者(非恶性肿瘤组)静脉血,采用ELISA法检测2组血清AGR2水平。收集结直肠癌患者年龄、性别比例、分化程度、肿瘤直径、淋巴结转移情况、神经及脉管侵犯等临床资料,比较不同临床特征结直肠癌患者血清AGR2水平。绘制ROC曲线,评估血清AGR2水平对结直肠癌的诊断效能。结果结直肠癌组血清AGR2水平[(384.44±270.67)ng/L]高于非恶性肿瘤组[(167.40±79.82)ng/L](t=5.002,P<0.001);结直肠癌临床分期Ⅲ~Ⅳ期者血清AGR2水平[(544.56±333.17)ng/L]高于临床分期Ⅰ~Ⅱ期者[(296.10±181.45)ng/L](t=-2.765,P=0.012),有脉管侵犯者血清AGR2水平[(487.41±311.76)ng/L]高于无脉管侵犯者[(321.93±225.97)ng/L](t=2.061,P=0.045)。不同年龄、性别、肿瘤分化程度、肿瘤直径及有无神经侵犯的结直肠癌患者血清AGR2水平比较差异均无统计学意义(P>0.05)。当血清AGR2水平的最佳截断值为201 ng/L时,其诊断结直肠癌的AUC为0.800(95%CI:0.695~0.906,P<0.001),灵敏度为73%,特异度为84%。结论结直肠癌患者血清AGR2蛋白水平高于肠道非恶性肿瘤,AGR2蛋白水平升高提示有发生淋巴结转移、脉管侵犯的可能,其对结直肠癌诊断有一定价值。
Objective To observe the correlation between serum anterior gradient 2(AGR2)and the clinicopathological features in patients with colorectal cancer,and to investigate the value of AGR2 protein to the diagnosis of colorectal cancer.Methods The serum levels of AGR2 protein were detected by ELISA in 45 patients with colorectal cancer(cancer group)and 25 patients with non-malignant intestinal tumor(non-malignant tumor group).The clinical data as age,gender,degree of differentiation,tumor diameter,lymph node metastasis,nerve invasion,and vascular invasion were collected in cancer group.The serum AGR2 levels were compared in patients with different clinicopathological features in cancer group.ROC curve was drawn to analyze the diagnostic efficiency of serum AGR2 protein.Results The serum AGR2 protein level was higher in cancer group[(384.44±270.67)ng/L]than that in non-malignant tumor group[(167.40±79.82)ng/L](t=5.002,P<0.001),higher in patients with clinical stageⅢ-Ⅳ[(544.56±333.173)ng/L]than that in clinical stageⅠ-Ⅱ[(296.10±181.45)ng/L]in cancer group(t=-2.765,P=0.012),higher in patients with vascular invasion[(487.41±311.76)ng/L]than that in patients without vascular invasion[(321.93±225.97)ng/L](t=2.061,P=0.045),and showed no significant differences in patients with different age,gender,differentiation degree,tumor diameter and presence and absence of nerve invasion(P>0.05).When the optimal cut-off value of serum AGR2 protein was 201 ng/L,the AUC for the diagnosis of colorectal cancer was 0.800(95%CI:0.695-0.906,P<0.001),with a sensitivity of 73%and a specificity of 84%.Conclusions The serum AGR2 protein is higher in patients with colorectal cancer than that in patients with non-malignant intestinal tumor.The high level of AGR2 protein indicates a high risk of lymph node metastasis and vascular invasion,and has a certain value to the diagnosis of colorectal cancer.
作者
来比江·吾斯曼
艾热提·吾杰克
宋钉町
张文斌
高华
Laibijiang WUSIMAN;Aireti WUJIEKE;SONG Ding-ding;ZHANG Wen-bin;GAO Hua(Department of Gastrointestinal Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830054,China)
出处
《中华实用诊断与治疗杂志》
2021年第12期1237-1239,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
新疆维吾尔自治区卫生健康委青年科技创新基金项目(WJWY-202149)。
关键词
结直肠癌
肠道非恶性肿瘤
前梯度同源蛋白2
colorectal cancer
non-malignant intestinal tumors
anterior gradient 2
