摘要
目的分析替格瑞洛和氯吡格雷对急性心肌梗死(AMI)患者PCI术后的疗效和医疗成本。方法方便选取2016年12月—2019年8月该院行PCI术的AMI患者1173例纳入该次研究,其中根据抗血小板治疗药物的不同取607例纳入观察组(使用阿司匹林及替格瑞洛),剩余566例纳入对照组(使用阿司匹林及氯吡格雷),比较两组总有效率、术前术后的左室舒张末径(LVDD)、左室射血分数(EF)、BNP、肌钙蛋白、尿素氮和潜血情况。计算出两组医疗成本,同时对成本及成本构成比开展比较和分析。结果观察组的总有效率是96.05%,高于对照组,差异有统计学意义(χ^(2)=60.452,P<0.05)。术后1周,观察组LVDD与对照组差异无统计学意义(P>0.05),EF比对照组更高,差异有统计学意义(P<0.05)。两组患者治疗前后BNP、潜血、BUN差异无统计学意义(P>0.05),肌钙蛋白差异差异有统计学意义(P<0.05)。观察组人均医疗成本(41676.95±14428.61)元低于对照组,两组比较差异有统计学意义(t=4.112,P<0.05)。结论对PCI术后AMI患者应用替格瑞洛较氯吡格雷疗效更佳,同时在节约非手术成本方面更具优势。
Objective To analyze the efficacy and medical cost of ticagrelor and clopidogrel for patients with acute myocardial infarction(AMI)after PCI.Methods From December 2016 to August 2019,1173 patients with AMI who underwent PCI in the hospital were conveniently selected to be included in the study,of which 607 cases were included in the observation group(using aspirin and ticagrelor)according to the difference in antiplatelet therapy drugs.566 cases were included in the control group(using aspirin and clopidogrel)to compare the total effective rate,left ventricular end diastolic diameter(LVDD),left ventricular ejection fraction(EF),BNP,troponin,Urea nitrogen and occult blood conditions.Calculated the two sets of medical costs,and compared and analyzed the cost and cost composition ratio at the same time.Results The total effective rate of the observation group was 96.05%higher than that of the control group,and the difference was statistically significant(χ^(2)=60.452,P<0.05).One week after operation,there was no significant difference in LVDD between the observation group and the control group(P>0.05).The EF was higher than the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in BNP,occult blood,BUN between the two groups of patients before and after treatment(P>0.05),but the difference in troponin was statistically significant(P<0.05).The per capita medical cost of the observation group(41676.95±14428.61)yuan was lower than that of the control group,and the difference between the two groups was statistically significant(t=4.112,P<0.05).Conclusion The use of ticagrelor in patients with AMI after PCI has a better curative effect than clopidogrel,and it has advantages in saving non-surgical costs.
作者
彭昊
秦又发
PENG Hao;QIN Youfa(Department of Pharmacy,Dongguan Songshan Lake Central Hospital(Dongguan Third People's Hospital),Dongguan,Guangdong Province,523382 China)
出处
《中外医疗》
2021年第30期111-114,共4页
China & Foreign Medical Treatment
基金
2020年东莞市社会科技发展(一般)项目(202050715024893)。
关键词
急性心肌梗死
替格瑞洛
氯吡格雷
疗效
医疗成本
Acute myocardial infarction
Ticagrelor
Clopidogrel
Therapeutic effect
Medical cost
